TRIM45 protein (Homo sapiens) - STRING network view

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TRIM45

tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway (580 aa)

Predicted Functional Partners:

UEVLD

0.876

SPG20

0.870

STAC

0.818

SORBS1

0.817

FCHSD2

0.815

TRIM41

0.812

TRAT1

0.747

KIR2DL1

0.646

KIR2DL2

0.634

CDK2

0.630

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK2	FCHSD2	ENSP00000266970	ENSP00000386722	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	FCH and double SH3 domains 2	0.506
CDK2	SORBS1	ENSP00000266970	ENSP00000355136	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	sorbin and SH3 domain containing 1	0.516
CDK2	SPG20	ENSP00000266970	ENSP00000347314	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both	0.568
CDK2	STAC	ENSP00000266970	ENSP00000273183	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction	0.474
CDK2	TRIM45	ENSP00000266970	ENSP00000256649	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway	0.630
CDK2	UEVLD	ENSP00000266970	ENSP00000379500	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination	0.568
FCHSD2	CDK2	ENSP00000386722	ENSP00000266970	FCH and double SH3 domains 2	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	0.506
FCHSD2	KIR2DL1	ENSP00000386722	ENSP00000336769	FCH and double SH3 domains 2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	0.416
FCHSD2	KIR2DL2	ENSP00000386722	ENSP00000383672	FCH and double SH3 domains 2	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells	0.535
FCHSD2	SORBS1	ENSP00000386722	ENSP00000355136	FCH and double SH3 domains 2	sorbin and SH3 domain containing 1	0.659
FCHSD2	SPG20	ENSP00000386722	ENSP00000347314	FCH and double SH3 domains 2	spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both	0.729
FCHSD2	STAC	ENSP00000386722	ENSP00000273183	FCH and double SH3 domains 2	SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction	0.722
FCHSD2	TRIM45	ENSP00000386722	ENSP00000256649	FCH and double SH3 domains 2	tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway	0.815
FCHSD2	UEVLD	ENSP00000386722	ENSP00000379500	FCH and double SH3 domains 2	UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination	0.757
KIR2DL1	FCHSD2	ENSP00000336769	ENSP00000386722	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	FCH and double SH3 domains 2	0.416
KIR2DL1	SORBS1	ENSP00000336769	ENSP00000355136	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	sorbin and SH3 domain containing 1	0.643
KIR2DL1	SPG20	ENSP00000336769	ENSP00000347314	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both	0.637
KIR2DL1	STAC	ENSP00000336769	ENSP00000273183	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction	0.472
KIR2DL1	TRIM45	ENSP00000336769	ENSP00000256649	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway	0.646
KIR2DL1	UEVLD	ENSP00000336769	ENSP00000379500	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination	0.569

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