| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AANAT | SLC38A2 | ENSP00000250615 | ENSP00000256689 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.768 |
| ATF4 | RPS6 | ENSP00000336790 | ENSP00000369757 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA | 0.436 |
| ATF4 | SLC38A2 | ENSP00000336790 | ENSP00000256689 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.889 |
| ATF4 | UBC | ENSP00000336790 | ENSP00000344818 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | ubiquitin C | 0.982 |
| COX5A | SLC38A2 | ENSP00000317780 | ENSP00000256689 | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.644 |
| COX5A | UBC | ENSP00000317780 | ENSP00000344818 | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | ubiquitin C | 0.546 |
| MCU | SLC38A2 | ENSP00000362144 | ENSP00000256689 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.644 |
| MCU | UBC | ENSP00000362144 | ENSP00000344818 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | ubiquitin C | 0.655 |
| PBX2 | SLC38A2 | ENSP00000364190 | ENSP00000256689 | pre-B-cell leukemia homeobox 2; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1 | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.721 |
| RPS6 | ATF4 | ENSP00000369757 | ENSP00000336790 | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | 0.436 |
| RPS6 | SLC36A1 | ENSP00000369757 | ENSP00000243389 | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA | solute carrier family 36 (proton/amino acid symporter), member 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity) | 0.513 |
| RPS6 | SLC38A2 | ENSP00000369757 | ENSP00000256689 | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.844 |
| RPS6 | UBC | ENSP00000369757 | ENSP00000344818 | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA | ubiquitin C | 0.981 |
| SCN11A | SLC38A2 | ENSP00000307599 | ENSP00000256689 | sodium channel, voltage-gated, type XI, alpha subunit; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.754 |
| SCN11A | UBC | ENSP00000307599 | ENSP00000344818 | sodium channel, voltage-gated, type XI, alpha subunit; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization | ubiquitin C | 0.412 |
| SLC36A1 | RPS6 | ENSP00000243389 | ENSP00000369757 | solute carrier family 36 (proton/amino acid symporter), member 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity) | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA | 0.513 |
| SLC36A1 | SLC38A2 | ENSP00000243389 | ENSP00000256689 | solute carrier family 36 (proton/amino acid symporter), member 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity) | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.703 |
| SLC36A2 | SLC38A2 | ENSP00000334223 | ENSP00000256689 | solute carrier family 36 (proton/amino acid symporter), member 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity) | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | 0.706 |
| SLC38A2 | AANAT | ENSP00000256689 | ENSP00000250615 | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | 0.768 |
| SLC38A2 | ATF4 | ENSP00000256689 | ENSP00000336790 | solute carrier family 38, member 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1-1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | 0.889 |
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