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SMIM3 SMIM3 MYO1A MYO1A SLC34A3 SLC34A3 SLC34A1 SLC34A1 EMP1 EMP1 LOH12CR1 LOH12CR1 FGF23 FGF23 CYP27B1 CYP27B1 PTH PTH CACNG6 CACNG6 CDC42EP2 CDC42EP2
"EMP1" - epithelial membrane protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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Experiments
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[Homology]
Score
EMP1epithelial membrane protein 1 (157 aa)    
Predicted Functional Partners:
LOH12CR1
loss of heterozygosity, 12, chromosomal region 1 (196 aa)
             score_image   0.624
SLC34A3
solute carrier family 34 (sodium phosphate), member 3; May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx (599 aa)
             score_image   0.610
MYO1A
myosin IA; Involved in directing the movement of organelles along actin filaments (Potential) (1043 aa)
             score_image   0.608
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1; Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation (508 aa)
             score_image   0.606
PTH
parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (115 aa)
             score_image   0.584
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (210 aa)
             score_image   0.571
SMIM3
small integral membrane protein 3 (60 aa)
         score_image       0.512
SLC34A1
solute carrier family 34 (sodium phosphate), member 1; May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx (639 aa)
             score_image   0.510
FGF23
fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization (251 aa)
             score_image   0.502
CACNG6
calcium channel, voltage-dependent, gamma subunit 6; Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity) (260 aa)
             score_image   0.493
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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