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MAP3K19 MAP3K19 SPATA13 SPATA13 NCF4 NCF4 SH3PXD2B SH3PXD2B RND1 RND1 SH3PXD2A SH3PXD2A ACLY ACLY MAP3K3 MAP3K3 RERG RERG MAP3K2 MAP3K2 GREB1 GREB1
"RERG" - RAS-like, estrogen-regulated, growth inhibitor in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Predicted Interactions
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RERGRAS-like, estrogen-regulated, growth inhibitor; Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential (199 aa)    
Predicted Functional Partners:
MAP3K19
mitogen-activated protein kinase kinase kinase 19 (1328 aa)
        score_image   score_image   0.709
MAP3K3
mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators (657 aa)
        score_image   score_image   0.709
MAP3K2
mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics (619 aa)
        score_image   score_image   0.709
RND1
Rho family GTPase 1; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (232 aa)
    score_image   score_image   score_image   0.703
SPATA13
spermatogenesis associated 13 (1277 aa)
        score_image   score_image   0.691
NCF4
neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex (348 aa)
        score_image   score_image   0.670
SH3PXD2A
SH3 and PX domains 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide (1105 aa)
        score_image   score_image   0.670
SH3PXD2B
SH3 and PX domains 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) (911 aa)
        score_image   score_image   0.670
GREB1
growth regulation by estrogen in breast cancer 1 (1949 aa)
            score_image   0.656
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
      score_image score_image   score_image   0.622
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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