node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB1 | ALB | ENSP00000265724 | ENSP00000295897 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | albumin | 0.517 |
ABCB1 | NR1I2 | ENSP00000265724 | ENSP00000336528 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | nuclear receptor subfamily 1, group I, member 2 | 0.957 |
ABCB1 | SLC10A1 | ENSP00000265724 | ENSP00000216540 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.507 |
ABCB1 | SLC22A8 | ENSP00000265724 | ENSP00000337335 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.636 |
ABCB1 | SLCO1B1 | ENSP00000265724 | ENSP00000256958 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.833 |
ABCB11 | ALB | ENSP00000263817 | ENSP00000295897 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | albumin | 0.412 |
ABCB11 | FABP6 | ENSP00000263817 | ENSP00000377549 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.757 |
ABCB11 | NR1I2 | ENSP00000263817 | ENSP00000336528 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 1, group I, member 2 | 0.957 |
ABCB11 | SLC10A1 | ENSP00000263817 | ENSP00000216540 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.917 |
ABCB11 | SLC22A8 | ENSP00000263817 | ENSP00000337335 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.543 |
ABCB11 | SLCO1B1 | ENSP00000263817 | ENSP00000256958 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.851 |
ABCC2 | ALB | ENSP00000359478 | ENSP00000295897 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | albumin | 0.472 |
ABCC2 | FABP6 | ENSP00000359478 | ENSP00000377549 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.416 |
ABCC2 | NR1I2 | ENSP00000359478 | ENSP00000336528 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | nuclear receptor subfamily 1, group I, member 2 | 0.947 |
ABCC2 | SLC10A1 | ENSP00000359478 | ENSP00000216540 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.778 |
ABCC2 | SLC22A8 | ENSP00000359478 | ENSP00000337335 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.749 |
ABCC2 | SLCO1B1 | ENSP00000359478 | ENSP00000256958 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.886 |
ABCC3 | ALB | ENSP00000285238 | ENSP00000295897 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | albumin | 0.925 |
ABCC3 | FABP6 | ENSP00000285238 | ENSP00000377549 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.933 |
ABCC3 | NR1I2 | ENSP00000285238 | ENSP00000336528 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | nuclear receptor subfamily 1, group I, member 2 | 0.633 |