node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP1 | ACP2 | ENSP00000272065 | ENSP00000256997 | acid phosphatase 1, soluble; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity | acid phosphatase 2, lysosomal | 0.810 |
ACP1 | GOT2 | ENSP00000272065 | ENSP00000245206 | acid phosphatase 1, soluble; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.655 |
ACP2 | ACP1 | ENSP00000256997 | ENSP00000272065 | acid phosphatase 2, lysosomal | acid phosphatase 1, soluble; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity | 0.810 |
ACP2 | DNAJB11 | ENSP00000256997 | ENSP00000265028 | acid phosphatase 2, lysosomal | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | 0.644 |
ACP2 | GOT2 | ENSP00000256997 | ENSP00000245206 | acid phosphatase 2, lysosomal | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.597 |
ACP2 | HBA2 | ENSP00000256997 | ENSP00000251595 | acid phosphatase 2, lysosomal | hemoglobin, alpha 2 | 0.534 |
ACP2 | LDHA | ENSP00000256997 | ENSP00000445175 | acid phosphatase 2, lysosomal | lactate dehydrogenase A | 0.670 |
ACP2 | M6PR | ENSP00000256997 | ENSP00000000412 | acid phosphatase 2, lysosomal | mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex | 0.644 |
ACP2 | MDH2 | ENSP00000256997 | ENSP00000327070 | acid phosphatase 2, lysosomal | malate dehydrogenase 2, NAD (mitochondrial) | 0.576 |
ACP2 | NIF3L1 | ENSP00000256997 | ENSP00000386394 | acid phosphatase 2, lysosomal | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.644 |
ACP2 | TMEM158 | ENSP00000256997 | ENSP00000422431 | acid phosphatase 2, lysosomal | transmembrane protein 158 (gene/pseudogene); Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide (By similarity) | 0.610 |
ACP2 | UQCRFS1 | ENSP00000256997 | ENSP00000306397 | acid phosphatase 2, lysosomal | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis | 0.644 |
DNAJB11 | ACP2 | ENSP00000265028 | ENSP00000256997 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | acid phosphatase 2, lysosomal | 0.644 |
GOT2 | ACP1 | ENSP00000245206 | ENSP00000272065 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | acid phosphatase 1, soluble; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity | 0.655 |
GOT2 | ACP2 | ENSP00000245206 | ENSP00000256997 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | acid phosphatase 2, lysosomal | 0.597 |
GOT2 | LDHA | ENSP00000245206 | ENSP00000445175 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | lactate dehydrogenase A | 0.784 |
GOT2 | MDH2 | ENSP00000245206 | ENSP00000327070 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | malate dehydrogenase 2, NAD (mitochondrial) | 0.995 |
HBA2 | ACP2 | ENSP00000251595 | ENSP00000256997 | hemoglobin, alpha 2 | acid phosphatase 2, lysosomal | 0.534 |
HBA2 | TMEM158 | ENSP00000251595 | ENSP00000422431 | hemoglobin, alpha 2 | transmembrane protein 158 (gene/pseudogene); Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide (By similarity) | 0.518 |
LDHA | ACP2 | ENSP00000445175 | ENSP00000256997 | lactate dehydrogenase A | acid phosphatase 2, lysosomal | 0.670 |