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STRINGSTRING
MDH2 MDH2 UQCRFS1 UQCRFS1 GOT2 GOT2 ACP1 ACP1 LDHA LDHA ACP2 ACP2 NIF3L1 NIF3L1 M6PR M6PR TMEM158 TMEM158 DNAJB11 DNAJB11 HBA2 HBA2
"ACP2" - acid phosphatase 2, lysosomal in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Known Interactions
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experiment edge
experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining edge
textmining
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co-expression
homology edge
protein homology
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Score
ACP2acid phosphatase 2, lysosomal (423 aa)    
Predicted Functional Partners:
ACP1
acid phosphatase 1, soluble; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity (158 aa)
            score_image   0.810
LDHA
lactate dehydrogenase A (361 aa)
            score_image   0.670
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) (377 aa)
        score_image       0.644
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (274 aa)
        score_image       0.644
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (358 aa)
        score_image       0.644
M6PR
mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (277 aa)
        score_image       0.644
TMEM158
transmembrane protein 158 (gene/pseudogene); Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide (By similarity) (300 aa)
            score_image   0.610
GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (430 aa)
            score_image   0.597
MDH2
malate dehydrogenase 2, NAD (mitochondrial) (338 aa)
            score_image   0.576
HBA2
hemoglobin, alpha 2 (142 aa)
            score_image   0.534
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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