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KLK7 KLK7 JUP JUP DSG1 DSG1 PKP3 PKP3 USP1 USP1 DSC1 DSC1 PKP2 PKP2 PKP1 PKP1 DSP DSP DSG2 DSG2 KRT16 KRT16
"DSC1" - desmocollin 1 in Homo sapiens
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DSC1desmocollin 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues (894 aa)    
Predicted Functional Partners:
PKP1
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis (747 aa)
        score_image   score_image   0.969
PKP3
plakophilin 3; May play a role in junctional plaques (797 aa)
        score_image   score_image   0.954
JUP
junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] (745 aa)
        score_image   score_image   0.949
PKP2
plakophilin 2; May play a role in junctional plaques (881 aa)
        score_image   score_image   0.901
KRT16
keratin 16 (473 aa)
            score_image   0.896
DSP
desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes (2871 aa)
        score_image   score_image   0.829
USP1
ubiquitin specific peptidase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (785 aa)
        score_image       0.740
DSG1
desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (1049 aa)
        score_image   score_image score_image 0.684
DSG2
desmoglein 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (1118 aa)
        score_image   score_image score_image 0.664
KLK7
kallikrein-related peptidase 7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at ’6-Leu-|-Cys-7’, ’16-Tyr-|-Leu-17’, ’25-Phe-|-Tyr-26’ and ’26-Tyr-|-Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines (253 aa)
            score_image   0.635
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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