node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSNK2A1 | FHOD3 | ENSP00000217244 | ENSP00000257209 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | formin homology 2 domain containing 3 | 0.576 |
CSNK2A1 | SMO | ENSP00000217244 | ENSP00000249373 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | smoothened, frizzled family receptor; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog’s proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia | 0.700 |
CSNK2A1 | SQSTM1 | ENSP00000217244 | ENSP00000374455 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | sequestosome 1; Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, ap [...] | 0.907 |
FAM101B | FHOD3 | ENSP00000331915 | ENSP00000257209 | family with sequence similarity 101, member B | formin homology 2 domain containing 3 | 0.495 |
FAM101B | MURC | ENSP00000331915 | ENSP00000418668 | family with sequence similarity 101, member B | muscle-related coiled-coil protein; Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway | 0.582 |
FHOD3 | CSNK2A1 | ENSP00000257209 | ENSP00000217244 | formin homology 2 domain containing 3 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.576 |
FHOD3 | FAM101B | ENSP00000257209 | ENSP00000331915 | formin homology 2 domain containing 3 | family with sequence similarity 101, member B | 0.495 |
FHOD3 | FLNB | ENSP00000257209 | ENSP00000420213 | formin homology 2 domain containing 3 | filamin B, beta | 0.742 |
FHOD3 | MURC | ENSP00000257209 | ENSP00000418668 | formin homology 2 domain containing 3 | muscle-related coiled-coil protein; Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway | 0.483 |
FHOD3 | NES | ENSP00000257209 | ENSP00000357206 | formin homology 2 domain containing 3 | nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | 0.685 |
FHOD3 | RAC1 | ENSP00000257209 | ENSP00000348461 | formin homology 2 domain containing 3 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.464 |
FHOD3 | RHOG | ENSP00000257209 | ENSP00000339467 | formin homology 2 domain containing 3 | ras homolog family member G; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry | 0.621 |
FHOD3 | SLC25A1 | ENSP00000257209 | ENSP00000215882 | formin homology 2 domain containing 3 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway | 0.516 |
FHOD3 | SMO | ENSP00000257209 | ENSP00000249373 | formin homology 2 domain containing 3 | smoothened, frizzled family receptor; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog’s proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia | 0.482 |
FHOD3 | SQSTM1 | ENSP00000257209 | ENSP00000374455 | formin homology 2 domain containing 3 | sequestosome 1; Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, ap [...] | 0.603 |
FLNB | FHOD3 | ENSP00000420213 | ENSP00000257209 | filamin B, beta | formin homology 2 domain containing 3 | 0.742 |
FLNB | RAC1 | ENSP00000420213 | ENSP00000348461 | filamin B, beta | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.679 |
FLNB | SQSTM1 | ENSP00000420213 | ENSP00000374455 | filamin B, beta | sequestosome 1; Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, ap [...] | 0.598 |
MURC | FAM101B | ENSP00000418668 | ENSP00000331915 | muscle-related coiled-coil protein; Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway | family with sequence similarity 101, member B | 0.582 |
MURC | FHOD3 | ENSP00000418668 | ENSP00000257209 | muscle-related coiled-coil protein; Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway | formin homology 2 domain containing 3 | 0.483 |