node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAZ1 | DAZ4 | ENSP00000384573 | ENSP00000401363 | deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | 0.571 |
DAZ1 | DAZL | ENSP00000384573 | ENSP00000250863 | deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells | deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) | 0.920 |
DAZ1 | DZIP1 | ENSP00000384573 | ENSP00000257312 | deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | 0.989 |
DAZ1 | HMMR | ENSP00000384573 | ENSP00000377492 | deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity | 0.440 |
DAZ4 | DAZ1 | ENSP00000401363 | ENSP00000384573 | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells | 0.571 |
DAZ4 | DAZL | ENSP00000401363 | ENSP00000250863 | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) | 0.599 |
DAZ4 | DZIP1 | ENSP00000401363 | ENSP00000257312 | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | 0.893 |
DAZ4 | HMMR | ENSP00000401363 | ENSP00000377492 | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity | 0.562 |
DAZL | DAZ1 | ENSP00000250863 | ENSP00000384573 | deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) | deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells | 0.920 |
DAZL | DAZ4 | ENSP00000250863 | ENSP00000401363 | deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | 0.599 |
DAZL | DZIP1 | ENSP00000250863 | ENSP00000257312 | deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | 0.757 |
DAZL | HMMR | ENSP00000250863 | ENSP00000377492 | deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity | 0.527 |
DZIP1 | DAZ1 | ENSP00000257312 | ENSP00000384573 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells | 0.989 |
DZIP1 | DAZ4 | ENSP00000257312 | ENSP00000401363 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | 0.893 |
DZIP1 | DAZL | ENSP00000257312 | ENSP00000250863 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) | 0.757 |
DZIP1 | GLI3 | ENSP00000257312 | ENSP00000379258 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | GLI family zinc finger 3; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulatin [...] | 0.832 |
DZIP1 | HMMR | ENSP00000257312 | ENSP00000377492 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity | 0.748 |
DZIP1 | OTP | ENSP00000257312 | ENSP00000302814 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | orthopedia homeobox; Probably involved in the differentiation of hypothalamic neuroendocrine cells | 0.675 |
DZIP1 | PPP2CA | ENSP00000257312 | ENSP00000418447 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ | 0.594 |
DZIP1 | PPP2R5C | ENSP00000257312 | ENSP00000412324 | DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ | protein phosphatase 2, regulatory subunit B’, gamma; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation | 0.567 |