USP30 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

USP30

ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology (517 aa)

Predicted Functional Partners:

ATXN7L3

0.912

USP1

0.902

FIS1

0.860

MPND

0.748

QKI

0.740

SS18L1

0.740

CLPB

0.740

SF3A1

0.740

USP50

0.722

USP19

0.705

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN7L3	USP30	ENSP00000397259	ENSP00000257548	ataxin 7-like 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into [...]	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.912
CLPB	USP30	ENSP00000294053	ENSP00000257548	ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.740
FIS1	USP1	ENSP00000223136	ENSP00000343526	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	ubiquitin specific peptidase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity	0.400
FIS1	USP30	ENSP00000223136	ENSP00000257548	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.860
MPND	USP30	ENSP00000262966	ENSP00000257548	MPN domain containing; Probable protease (By similarity)	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.748
QKI	USP30	ENSP00000355094	ENSP00000257548	QKI, KH domain containing, RNA binding	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.740
SF3A1	USP30	ENSP00000215793	ENSP00000257548	splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.740
SS18L1	USP30	ENSP00000333012	ENSP00000257548	synovial sarcoma translocation gene on chromosome 18-like 1	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.740
USP1	FIS1	ENSP00000343526	ENSP00000223136	ubiquitin specific peptidase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	0.400
USP1	USP30	ENSP00000343526	ENSP00000257548	ubiquitin specific peptidase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.902
USP19	USP30	ENSP00000401197	ENSP00000257548	ubiquitin specific peptidase 19	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.705
USP30	ATXN7L3	ENSP00000257548	ENSP00000397259	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	ataxin 7-like 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into [...]	0.912
USP30	CLPB	ENSP00000257548	ENSP00000294053	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process	0.740
USP30	FIS1	ENSP00000257548	ENSP00000223136	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	0.860
USP30	MPND	ENSP00000257548	ENSP00000262966	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	MPN domain containing; Probable protease (By similarity)	0.748
USP30	QKI	ENSP00000257548	ENSP00000355094	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	QKI, KH domain containing, RNA binding	0.740
USP30	SF3A1	ENSP00000257548	ENSP00000215793	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.740
USP30	SS18L1	ENSP00000257548	ENSP00000333012	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	synovial sarcoma translocation gene on chromosome 18-like 1	0.740
USP30	USP1	ENSP00000257548	ENSP00000343526	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	ubiquitin specific peptidase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity	0.902
USP30	USP19	ENSP00000257548	ENSP00000401197	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	ubiquitin specific peptidase 19	0.705

page 1 of 2

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About