node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDKN1A | MSI1 | ENSP00000244741 | ENSP00000257552 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | musashi homolog 1 (Drosophila); RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5’- GUUAGUUAGUUAGUU-3’ and other sequences containing the pattern 5’- [GA]U(1-3)AGU-3’. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity) | 0.819 |
CPSF4 | CSTF2 | ENSP00000292476 | ENSP00000362063 | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | 0.983 |
CPSF4 | CSTF2T | ENSP00000292476 | ENSP00000332444 | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) | 0.902 |
CPSF4 | CSTF3 | ENSP00000292476 | ENSP00000315791 | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs | 0.989 |
CPSF4 | MSI1 | ENSP00000292476 | ENSP00000257552 | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | musashi homolog 1 (Drosophila); RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5’- GUUAGUUAGUUAGUU-3’ and other sequences containing the pattern 5’- [GA]U(1-3)AGU-3’. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity) | 0.786 |
CPSF4 | SRSF4 | ENSP00000292476 | ENSP00000362900 | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 | 0.715 |
CPSF4 | SRSF6 | ENSP00000292476 | ENSP00000244020 | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 | 0.736 |
CSTF2 | CPSF4 | ENSP00000362063 | ENSP00000292476 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | 0.983 |
CSTF2 | CSTF3 | ENSP00000362063 | ENSP00000315791 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs | 0.999 |
CSTF2 | MSI1 | ENSP00000362063 | ENSP00000257552 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | musashi homolog 1 (Drosophila); RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5’- GUUAGUUAGUUAGUU-3’ and other sequences containing the pattern 5’- [GA]U(1-3)AGU-3’. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity) | 0.916 |
CSTF2 | SRSF4 | ENSP00000362063 | ENSP00000362900 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 | 0.968 |
CSTF2 | SRSF6 | ENSP00000362063 | ENSP00000244020 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 | 0.967 |
CSTF2T | CPSF4 | ENSP00000332444 | ENSP00000292476 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | 0.902 |
CSTF2T | CSTF3 | ENSP00000332444 | ENSP00000315791 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) | cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs | 0.998 |
CSTF2T | MSI1 | ENSP00000332444 | ENSP00000257552 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) | musashi homolog 1 (Drosophila); RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5’- GUUAGUUAGUUAGUU-3’ and other sequences containing the pattern 5’- [GA]U(1-3)AGU-3’. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity) | 0.916 |
CSTF2T | SRSF4 | ENSP00000332444 | ENSP00000362900 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 | 0.640 |
CSTF2T | SRSF6 | ENSP00000332444 | ENSP00000244020 | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) | serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 | 0.640 |
CSTF3 | CPSF4 | ENSP00000315791 | ENSP00000292476 | cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs | cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) | 0.989 |
CSTF3 | CSTF2 | ENSP00000315791 | ENSP00000362063 | cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | 0.999 |
CSTF3 | CSTF2T | ENSP00000315791 | ENSP00000332444 | cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs | cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) | 0.998 |