Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
LDB1 LDB1 TAL1 TAL1 LDB2 LDB2 LYL1 LYL1 GATA3 GATA3 TCF3 TCF3 GATA2 GATA2 GATA1 GATA1 LMO2 LMO2 NHLH1 NHLH1 ELF2 ELF2
"LMO2" - LIM domain only 2 (rhombotin-like 1) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LMO2LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state (227 aa)    
Predicted Functional Partners:
TAL1
T-cell acute lymphocytic leukemia 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) (331 aa)
      score_image score_image   score_image   0.999
LDB1
LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) (411 aa)
        score_image   score_image   0.999
GATA1
GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells (413 aa)
      score_image score_image   score_image   0.998
GATA2
GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’ (480 aa)
        score_image   score_image   0.978
LDB2
LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors (373 aa)
        score_image   score_image   0.973
GATA3
GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ (444 aa)
        score_image   score_image   0.963
NHLH1
nescient helix loop helix 1; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system (133 aa)
        score_image   score_image   0.944
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (654 aa)
            score_image   0.928
ELF2
E74-like factor 2 (ets domain transcription factor); Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter (581 aa)
        score_image   score_image   0.921
LYL1
lymphoblastic leukemia derived sequence 1 (280 aa)
        score_image   score_image   0.894
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (34%)