node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD63 | ITGB1 | ENSP00000257857 | ENSP00000303351 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.897 |
CD63 | LAMP1 | ENSP00000257857 | ENSP00000333298 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | 0.861 |
CD63 | LAMP2 | ENSP00000257857 | ENSP00000408411 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens | 0.831 |
CD63 | NPY | ENSP00000257857 | ENSP00000242152 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.826 |
CD63 | PTK2 | ENSP00000257857 | ENSP00000341189 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.851 |
CD63 | SCARB2 | ENSP00000257857 | ENSP00000264896 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.882 |
CD63 | SRC | ENSP00000257857 | ENSP00000350941 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.943 |
CD63 | SYT7 | ENSP00000257857 | ENSP00000263846 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | synaptotagmin VII; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity) | 0.864 |
CD63 | TIMP1 | ENSP00000257857 | ENSP00000218388 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | TIMP metallopeptidase inhibitor 1; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14 | 0.939 |
CD63 | UBC | ENSP00000257857 | ENSP00000344818 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | ubiquitin C | 0.909 |
ITGB1 | CD63 | ENSP00000303351 | ENSP00000257857 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | 0.897 |
ITGB1 | PTK2 | ENSP00000303351 | ENSP00000341189 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.981 |
ITGB1 | SRC | ENSP00000303351 | ENSP00000350941 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.940 |
ITGB1 | TIMP1 | ENSP00000303351 | ENSP00000218388 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | TIMP metallopeptidase inhibitor 1; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14 | 0.838 |
ITGB1 | UBC | ENSP00000303351 | ENSP00000344818 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | ubiquitin C | 0.944 |
LAMP1 | CD63 | ENSP00000333298 | ENSP00000257857 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | 0.861 |
LAMP1 | SCARB2 | ENSP00000333298 | ENSP00000264896 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.628 |
LAMP1 | SRC | ENSP00000333298 | ENSP00000350941 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.412 |
LAMP1 | SYT7 | ENSP00000333298 | ENSP00000263846 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | synaptotagmin VII; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity) | 0.501 |
LAMP1 | UBC | ENSP00000333298 | ENSP00000344818 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | ubiquitin C | 0.644 |