Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | LACRT | lacritin; Modulates secretion by lacrimal acinar cells (138 aa) | ||||||||||||
Predicted Functional Partners:
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 | SDC1 | syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (310 aa) |
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0.936 | |||||||||
 | NID1 | nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions (1247 aa) |
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0.885 | |||||||||
 | VTN | vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (478 aa) |
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0.854 | |||||||||
 | FBLN2 | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent (1231 aa) |
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0.758 | ||||||||||
 | LCN1 | lipocalin 1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket (176 aa) |
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0.643 | ||||||||||
 | FN1 | fibronectin 1 (2477 aa) |
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0.574 | |||||||||
 | MS4A14 | membrane-spanning 4-domains, subfamily A, member 14; May be involved in signal transduction as a component of a multimeric receptor complex (By similarity) (679 aa) |
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0.562 | ||||||||||
 | PIP | prolactin-induced protein (146 aa) |
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0.507 | ||||||||||
 | PRR4 | proline rich 4 (lacrimal) (134 aa) |
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0.503 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.491 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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