Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX12 | KRT85 | ENSP00000251535 | ENSP00000257901 | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | keratin 85 | 0.570 |
ATG10 | ATG3 | ENSP00000282185 | ENSP00000283290 | autophagy related 10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity) | autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 | 0.960 |
ATG10 | KRT85 | ENSP00000282185 | ENSP00000257901 | autophagy related 10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity) | keratin 85 | 0.955 |
ATG3 | ATG10 | ENSP00000283290 | ENSP00000282185 | autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 | autophagy related 10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity) | 0.960 |
ATG3 | KRT85 | ENSP00000283290 | ENSP00000257901 | autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 | keratin 85 | 0.694 |
ATG3 | UBC | ENSP00000283290 | ENSP00000344818 | autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 | ubiquitin C | 0.832 |
KRT85 | ALOX12 | ENSP00000257901 | ENSP00000251535 | keratin 85 | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | 0.570 |
KRT85 | ATG10 | ENSP00000257901 | ENSP00000282185 | keratin 85 | autophagy related 10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity) | 0.955 |
KRT85 | ATG3 | ENSP00000257901 | ENSP00000283290 | keratin 85 | autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 | 0.694 |
KRT85 | MLST8 | ENSP00000257901 | ENSP00000380313 | keratin 85 | MTOR associated protein, LST8 homolog (S. cerevisiae) | 0.569 |
KRT85 | OTUD4 | ENSP00000257901 | ENSP00000409279 | keratin 85 | OTU domain containing 4 | 0.740 |
KRT85 | RAB24 | ENSP00000257901 | ENSP00000304376 | keratin 85 | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) | 0.569 |
KRT85 | UBC | ENSP00000257901 | ENSP00000344818 | keratin 85 | ubiquitin C | 0.500 |
KRT85 | USP15 | ENSP00000257901 | ENSP00000258123 | keratin 85 | ubiquitin specific peptidase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed-21947082). According to another reports, regulates the TGF-beta receptor s [...] | 0.558 |
KRT85 | USP8 | ENSP00000257901 | ENSP00000302239 | keratin 85 | ubiquitin specific peptidase 8; Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both ’Lys-48’ an ’Lys-63’-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiqu [...] | 0.740 |
KRT85 | USPL1 | ENSP00000257901 | ENSP00000255304 | keratin 85 | ubiquitin specific peptidase like 1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation | 0.742 |
MLST8 | KRT85 | ENSP00000380313 | ENSP00000257901 | MTOR associated protein, LST8 homolog (S. cerevisiae) | keratin 85 | 0.569 |
MLST8 | UBC | ENSP00000380313 | ENSP00000344818 | MTOR associated protein, LST8 homolog (S. cerevisiae) | ubiquitin C | 0.802 |
OTUD4 | KRT85 | ENSP00000409279 | ENSP00000257901 | OTU domain containing 4 | keratin 85 | 0.740 |
OTUD4 | UBC | ENSP00000409279 | ENSP00000344818 | OTU domain containing 4 | ubiquitin C | 0.904 |
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