RC3H1 protein (Homo sapiens) - STRING network view

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RC3H1

ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity) (1133 aa)

Predicted Functional Partners:

CTLA4

0.896

NAA50

0.748

DDX1

0.667

CNR2

0.667

CDA

0.661

ZC3H10

0.654

ZC3H7B

0.651

ZC3H12C

0.624

RBM27

0.598

RBM26

0.590

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDA	RC3H1	ENSP00000364212	ENSP00000258349	cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	0.661
CNR2	NAA50	ENSP00000363596	ENSP00000240922	cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis	N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity	0.457
CNR2	RC3H1	ENSP00000363596	ENSP00000258349	cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	0.667
CTLA4	RC3H1	ENSP00000303939	ENSP00000258349	cytotoxic T-lymphocyte-associated protein 4	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	0.896
DDX1	RC3H1	ENSP00000233084	ENSP00000258349	DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...]	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	0.667
NAA50	CNR2	ENSP00000240922	ENSP00000363596	N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity	cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis	0.457
NAA50	RC3H1	ENSP00000240922	ENSP00000258349	N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	0.748
RBM26	RC3H1	ENSP00000267229	ENSP00000258349	RNA binding motif protein 26	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	0.590
RBM26	ZC3H10	ENSP00000267229	ENSP00000257940	RNA binding motif protein 26	zinc finger CCCH-type containing 10	0.697
RBM26	ZC3H12C	ENSP00000267229	ENSP00000278590	RNA binding motif protein 26	zinc finger CCCH-type containing 12C; May function as RNase and regulate the levels of target RNA species (Potential)	0.627
RBM27	RC3H1	ENSP00000265271	ENSP00000258349	RNA binding motif protein 27	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	0.598
RBM27	ZC3H10	ENSP00000265271	ENSP00000257940	RNA binding motif protein 27	zinc finger CCCH-type containing 10	0.685
RBM27	ZC3H12C	ENSP00000265271	ENSP00000278590	RNA binding motif protein 27	zinc finger CCCH-type containing 12C; May function as RNase and regulate the levels of target RNA species (Potential)	0.629
RC3H1	CDA	ENSP00000258349	ENSP00000364212	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis	0.661
RC3H1	CNR2	ENSP00000258349	ENSP00000363596	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis	0.667
RC3H1	CTLA4	ENSP00000258349	ENSP00000303939	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	cytotoxic T-lymphocyte-associated protein 4	0.896
RC3H1	DDX1	ENSP00000258349	ENSP00000233084	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...]	0.667
RC3H1	NAA50	ENSP00000258349	ENSP00000240922	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity	0.748
RC3H1	RBM26	ENSP00000258349	ENSP00000267229	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	RNA binding motif protein 26	0.590
RC3H1	RBM27	ENSP00000258349	ENSP00000265271	ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity)	RNA binding motif protein 27	0.598

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