node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGTR1 | EDN1 | ENSP00000273430 | ENSP00000368683 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.956 |
AGTR1 | GNA11 | ENSP00000273430 | ENSP00000078429 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.931 |
AGTR1 | GNAQ | ENSP00000273430 | ENSP00000286548 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.974 |
AGTR1 | GRM1 | ENSP00000273430 | ENSP00000282753 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | glutamate receptor, metabotropic 1 | 0.910 |
AGTR1 | GRM5 | ENSP00000273430 | ENSP00000306138 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | glutamate receptor, metabotropic 5; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current | 0.910 |
AGTR1 | HTR2B | ENSP00000273430 | ENSP00000258400 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior | 0.957 |
AGTR1 | KNG1 | ENSP00000273430 | ENSP00000265023 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.971 |
AGTR1 | NPS | ENSP00000273430 | ENSP00000381105 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.927 |
AGTR1 | OXT | ENSP00000273430 | ENSP00000217386 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin | 0.927 |
AGTR1 | PLCB3 | ENSP00000273430 | ENSP00000279230 | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.904 |
EDN1 | AGTR1 | ENSP00000368683 | ENSP00000273430 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.956 |
EDN1 | GNA11 | ENSP00000368683 | ENSP00000078429 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.931 |
EDN1 | GNAQ | ENSP00000368683 | ENSP00000286548 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.954 |
EDN1 | GRM1 | ENSP00000368683 | ENSP00000282753 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | glutamate receptor, metabotropic 1 | 0.911 |
EDN1 | GRM5 | ENSP00000368683 | ENSP00000306138 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | glutamate receptor, metabotropic 5; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current | 0.910 |
EDN1 | HTR2B | ENSP00000368683 | ENSP00000258400 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior | 0.939 |
EDN1 | KNG1 | ENSP00000368683 | ENSP00000265023 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.981 |
EDN1 | NPS | ENSP00000368683 | ENSP00000381105 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.954 |
EDN1 | OXT | ENSP00000368683 | ENSP00000217386 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin | 0.961 |
EDN1 | PLCB3 | ENSP00000368683 | ENSP00000279230 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.915 |