TMEM127 protein (Homo sapiens) - STRING network view

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TMEM127

transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor (238 aa)

Predicted Functional Partners:

ENSG00000256591

0.903

SDHAF2

0.822

SDHD

0.814

ENSG00000255292

0.757

SDHA

0.753

SDHB

0.751

RET

0.660

PGLS

0.658

NF1

0.648

SDHC

0.634

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000255292	ENSG00000256591	ENSP00000456434	ENSP00000443130	Uncharacterized protein	Uncharacterized protein	0.842
ENSG00000255292	NF1	ENSP00000456434	ENSP00000351015	Uncharacterized protein	neurofibromin 1; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity	0.660
ENSG00000255292	PGLS	ENSP00000456434	ENSP00000252603	Uncharacterized protein	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate	0.607
ENSG00000255292	RET	ENSP00000456434	ENSP00000347942	Uncharacterized protein	ret proto-oncogene; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer’s patch-like st [...]	0.725
ENSG00000255292	SDHA	ENSP00000456434	ENSP00000264932	Uncharacterized protein	succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor	0.980
ENSG00000255292	SDHAF2	ENSP00000456434	ENSP00000301761	Uncharacterized protein	succinate dehydrogenase complex assembly factor 2; Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment	0.784
ENSG00000255292	SDHB	ENSP00000456434	ENSP00000364649	Uncharacterized protein	succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.999
ENSG00000255292	SDHC	ENSP00000456434	ENSP00000356953	Uncharacterized protein	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.999
ENSG00000255292	TMEM127	ENSP00000456434	ENSP00000258439	Uncharacterized protein	transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor	0.757
ENSG00000256591	ENSG00000255292	ENSP00000443130	ENSP00000456434	Uncharacterized protein	Uncharacterized protein	0.842
ENSG00000256591	NF1	ENSP00000443130	ENSP00000351015	Uncharacterized protein	neurofibromin 1; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity	0.581
ENSG00000256591	PGLS	ENSP00000443130	ENSP00000252603	Uncharacterized protein	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate	0.633
ENSG00000256591	RET	ENSP00000443130	ENSP00000347942	Uncharacterized protein	ret proto-oncogene; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer’s patch-like st [...]	0.623
ENSG00000256591	SDHA	ENSP00000443130	ENSP00000264932	Uncharacterized protein	succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor	0.980
ENSG00000256591	SDHB	ENSP00000443130	ENSP00000364649	Uncharacterized protein	succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.929
ENSG00000256591	SDHC	ENSP00000443130	ENSP00000356953	Uncharacterized protein	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.767
ENSG00000256591	SDHD	ENSP00000443130	ENSP00000364699	Uncharacterized protein	succinate dehydrogenase complex, subunit D, integral membrane protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity)	0.843
ENSG00000256591	TMEM127	ENSP00000443130	ENSP00000258439	Uncharacterized protein	transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor	0.903
NF1	ENSG00000255292	ENSP00000351015	ENSP00000456434	neurofibromin 1; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity	Uncharacterized protein	0.660
NF1	ENSG00000256591	ENSP00000351015	ENSP00000443130	neurofibromin 1; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity	Uncharacterized protein	0.581

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