GPR45 protein (Homo sapiens) - STRING network view

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GPR45

G protein-coupled receptor 45; Orphan receptor. May play a role in brain function (372 aa)

Predicted Functional Partners:

LPAR2

0.580

LPAR1

0.537

RAD1

0.525

STK17A

0.485

STK17B

0.485

BACE1

0.482

LPAR3

0.472

GPR62

0.415

CALB2

0.405

CALB1

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BACE1	GPR45	ENSP00000318585	ENSP00000258456	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	0.482
CALB1	GPR45	ENSP00000265431	ENSP00000258456	calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	0.405
CALB1	STK17A	ENSP00000265431	ENSP00000319192	calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase	serine/threonine kinase 17a; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species	0.421
CALB1	STK17B	ENSP00000265431	ENSP00000263955	calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase	serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis	0.431
CALB2	GPR45	ENSP00000307508	ENSP00000258456	calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	0.405
CALB2	STK17A	ENSP00000307508	ENSP00000319192	calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons	serine/threonine kinase 17a; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species	0.421
CALB2	STK17B	ENSP00000307508	ENSP00000263955	calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons	serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis	0.421
GPR45	BACE1	ENSP00000258456	ENSP00000318585	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	0.482
GPR45	CALB1	ENSP00000258456	ENSP00000265431	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase	0.405
GPR45	CALB2	ENSP00000258456	ENSP00000307508	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons	0.405
GPR45	GPR62	ENSP00000258456	ENSP00000319250	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	G protein-coupled receptor 62; Orphan receptor	0.415
GPR45	LPAR1	ENSP00000258456	ENSP00000351755	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation	0.537
GPR45	LPAR2	ENSP00000258456	ENSP00000384665	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation	0.580
GPR45	LPAR3	ENSP00000258456	ENSP00000359643	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins	0.472
GPR45	RAD1	ENSP00000258456	ENSP00000340879	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...]	0.525
GPR45	STK17A	ENSP00000258456	ENSP00000319192	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	serine/threonine kinase 17a; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species	0.485
GPR45	STK17B	ENSP00000258456	ENSP00000263955	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis	0.485
GPR62	GPR45	ENSP00000319250	ENSP00000258456	G protein-coupled receptor 62; Orphan receptor	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	0.415
LPAR1	GPR45	ENSP00000351755	ENSP00000258456	lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation	G protein-coupled receptor 45; Orphan receptor. May play a role in brain function	0.537
LPAR1	LPAR2	ENSP00000351755	ENSP00000384665	lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation	lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation	0.904

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