ALDH1L2 protein (Homo sapiens) - STRING network view

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ALDH1L2

aldehyde dehydrogenase 1 family, member L2 (923 aa)

Predicted Functional Partners:

MTHFD2L

0.966

MTHFD1

0.963

MTHFD2

0.953

SHMT2

0.938

SHMT1

0.937

FTCD

0.921

MTR

0.915

DHFR

0.911

AMT

0.906

DHFRL1

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1L2	AMT	ENSP00000258494	ENSP00000273588	aldehyde dehydrogenase 1 family, member L2	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	0.906
ALDH1L2	DHFR	ENSP00000258494	ENSP00000396308	aldehyde dehydrogenase 1 family, member L2	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	0.911
ALDH1L2	DHFRL1	ENSP00000258494	ENSP00000319170	aldehyde dehydrogenase 1 family, member L2	dihydrofolate reductase-like 1; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR	0.900
ALDH1L2	FTCD	ENSP00000258494	ENSP00000291670	aldehyde dehydrogenase 1 family, member L2	formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool	0.921
ALDH1L2	MTHFD1	ENSP00000258494	ENSP00000450560	aldehyde dehydrogenase 1 family, member L2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.963
ALDH1L2	MTHFD2	ENSP00000258494	ENSP00000377617	aldehyde dehydrogenase 1 family, member L2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.953
ALDH1L2	MTHFD2L	ENSP00000258494	ENSP00000379108	aldehyde dehydrogenase 1 family, member L2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	0.966
ALDH1L2	MTR	ENSP00000258494	ENSP00000355536	aldehyde dehydrogenase 1 family, member L2	5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity)	0.915
ALDH1L2	SHMT1	ENSP00000258494	ENSP00000318868	aldehyde dehydrogenase 1 family, member L2	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.937
ALDH1L2	SHMT2	ENSP00000258494	ENSP00000333667	aldehyde dehydrogenase 1 family, member L2	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.938
AMT	ALDH1L2	ENSP00000273588	ENSP00000258494	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	aldehyde dehydrogenase 1 family, member L2	0.906
AMT	DHFR	ENSP00000273588	ENSP00000396308	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	0.925
AMT	DHFRL1	ENSP00000273588	ENSP00000319170	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	dihydrofolate reductase-like 1; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR	0.900
AMT	FTCD	ENSP00000273588	ENSP00000291670	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool	0.913
AMT	MTHFD1	ENSP00000273588	ENSP00000450560	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.981
AMT	MTHFD2	ENSP00000273588	ENSP00000377617	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.984
AMT	MTHFD2L	ENSP00000273588	ENSP00000379108	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	0.985
AMT	MTR	ENSP00000273588	ENSP00000355536	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity)	0.911
AMT	SHMT1	ENSP00000273588	ENSP00000318868	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.985
AMT	SHMT2	ENSP00000273588	ENSP00000333667	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.988

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