| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG4C | BECN1 | ENSP00000322159 | ENSP00000355231 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.766 |
| ATG4C | DRAM1 | ENSP00000322159 | ENSP00000258534 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | 0.472 |
| ATG4C | EDA | ENSP00000322159 | ENSP00000363680 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | ectodysplasin A | 0.659 |
| ATG4C | NUMA1 | ENSP00000322159 | ENSP00000377298 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | nuclear mitotic apparatus protein 1; Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions | 0.659 |
| ATG4C | PHB2 | ENSP00000322159 | ENSP00000441875 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.755 |
| ATG4C | SPTAN1 | ENSP00000322159 | ENSP00000361824 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | spectrin, alpha, non-erythrocytic 1 | 0.726 |
| BECN1 | ATG4C | ENSP00000355231 | ENSP00000322159 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | 0.766 |
| BECN1 | C12orf5 | ENSP00000355231 | ENSP00000179259 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | 0.408 |
| BECN1 | DRAM1 | ENSP00000355231 | ENSP00000258534 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | 0.564 |
| BECN1 | UVRAG | ENSP00000355231 | ENSP00000348455 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | UV radiation resistance associated | 0.999 |
| C12orf5 | BECN1 | ENSP00000179259 | ENSP00000355231 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.408 |
| C12orf5 | DRAM1 | ENSP00000179259 | ENSP00000258534 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | 0.471 |
| C12orf5 | SESN2 | ENSP00000179259 | ENSP00000253063 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | sestrin 2; Involved in the reduction of peroxiredoxins | 0.639 |
| C1orf21 | DRAM1 | ENSP00000235307 | ENSP00000258534 | chromosome 1 open reading frame 21 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | 0.613 |
| DRAM1 | ATG4C | ENSP00000258534 | ENSP00000322159 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | 0.472 |
| DRAM1 | BECN1 | ENSP00000258534 | ENSP00000355231 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.564 |
| DRAM1 | C12orf5 | ENSP00000258534 | ENSP00000179259 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | 0.471 |
| DRAM1 | C1orf21 | ENSP00000258534 | ENSP00000235307 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | chromosome 1 open reading frame 21 | 0.613 |
| DRAM1 | EDA | ENSP00000258534 | ENSP00000363680 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | ectodysplasin A | 0.485 |
| DRAM1 | NUMA1 | ENSP00000258534 | ENSP00000377298 | DNA-damage regulated autophagy modulator 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy | nuclear mitotic apparatus protein 1; Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions | 0.471 |
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