| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMIGO1 | RCBTB1 | ENSP00000358878 | ENSP00000258646 | adhesion molecule with Ig-like domain 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity) | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | 0.751 |
| CUL3 | RCBTB1 | ENSP00000264414 | ENSP00000258646 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | 0.664 |
| LRFN3 | RCBTB1 | ENSP00000246529 | ENSP00000258646 | leucine rich repeat and fibronectin type III domain containing 3; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity) | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | 0.662 |
| LRFN4 | RCBTB1 | ENSP00000312535 | ENSP00000258646 | leucine rich repeat and fibronectin type III domain containing 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity) | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | 0.753 |
| RAN | RANGRF | ENSP00000376176 | ENSP00000226105 | RAN, member RAS oncogene family | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | 0.995 |
| RAN | RCBTB1 | ENSP00000376176 | ENSP00000258646 | RAN, member RAS oncogene family | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | 0.662 |
| RANGRF | RAN | ENSP00000226105 | ENSP00000376176 | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | RAN, member RAS oncogene family | 0.995 |
| RANGRF | RCBTB1 | ENSP00000226105 | ENSP00000258646 | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | 0.680 |
| RCBTB1 | AMIGO1 | ENSP00000258646 | ENSP00000358878 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | adhesion molecule with Ig-like domain 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity) | 0.751 |
| RCBTB1 | CUL3 | ENSP00000258646 | ENSP00000264414 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | 0.664 |
| RCBTB1 | LRFN3 | ENSP00000258646 | ENSP00000246529 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | leucine rich repeat and fibronectin type III domain containing 3; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity) | 0.662 |
| RCBTB1 | LRFN4 | ENSP00000258646 | ENSP00000312535 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | leucine rich repeat and fibronectin type III domain containing 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity) | 0.753 |
| RCBTB1 | RAN | ENSP00000258646 | ENSP00000376176 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | RAN, member RAS oncogene family | 0.662 |
| RCBTB1 | RANGRF | ENSP00000258646 | ENSP00000226105 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | 0.680 |
| RCBTB1 | SETDB2 | ENSP00000258646 | ENSP00000326477 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis | 0.775 |
| RCBTB1 | SLIT1 | ENSP00000258646 | ENSP00000266058 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | slit homolog 1 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb | 0.656 |
| RCBTB1 | SPRYD7 | ENSP00000258646 | ENSP00000354774 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | SPRY domain containing 7 | 0.807 |
| RCBTB1 | TBPL1 | ENSP00000258646 | ENSP00000237264 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | TBP-like 1; Does not bind the TATA box. Has DNA-binding ability | 0.680 |
| SETDB2 | RCBTB1 | ENSP00000326477 | ENSP00000258646 | SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling | 0.775 |
| SETDB2 | SPRYD7 | ENSP00000326477 | ENSP00000354774 | SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis | SPRY domain containing 7 | 0.822 |
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