BZW2 protein (Homo sapiens) - STRING network view

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Score

BZW2

basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity) (419 aa)

Predicted Functional Partners:

UBC

0.938

EIF4G3

0.776

EIF4G1

0.776

BZW1

0.616

PSTPIP1

0.585

CNBP

0.571

LZTFL1

0.571

ABHD14A

0.544

GINS3

0.540

EIF6

0.538

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD14A	BZW2	ENSP00000273596	ENSP00000258761	abhydrolase domain containing 14A; Possible role in granule neuron development (By similarity)	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	0.544
ABHD14A	EIF6	ENSP00000273596	ENSP00000363559	abhydrolase domain containing 14A; Possible role in granule neuron development (By similarity)	eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity	0.482
ABHD14A	GINS3	ENSP00000273596	ENSP00000401018	abhydrolase domain containing 14A; Possible role in granule neuron development (By similarity)	GINS complex subunit 3 (Psf3 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA	0.538
BZW1	BZW2	ENSP00000394316	ENSP00000258761	basic leucine zipper and W2 domains 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	0.616
BZW1	EIF4G1	ENSP00000394316	ENSP00000338020	basic leucine zipper and W2 domains 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly	eukaryotic translation initiation factor 4 gamma, 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome	0.781
BZW1	EIF4G3	ENSP00000394316	ENSP00000364073	basic leucine zipper and W2 domains 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly	eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1	0.776
BZW1	LZTFL1	ENSP00000394316	ENSP00000296135	basic leucine zipper and W2 domains 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly	leucine zipper transcription factor-like 1	0.613
BZW1	UBC	ENSP00000394316	ENSP00000344818	basic leucine zipper and W2 domains 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly	ubiquitin C	0.943
BZW2	ABHD14A	ENSP00000258761	ENSP00000273596	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	abhydrolase domain containing 14A; Possible role in granule neuron development (By similarity)	0.544
BZW2	BZW1	ENSP00000258761	ENSP00000394316	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	basic leucine zipper and W2 domains 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly	0.616
BZW2	CNBP	ENSP00000258761	ENSP00000410769	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	CCHC-type zinc finger, nucleic acid binding protein	0.571
BZW2	EIF4G1	ENSP00000258761	ENSP00000338020	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	eukaryotic translation initiation factor 4 gamma, 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome	0.776
BZW2	EIF4G3	ENSP00000258761	ENSP00000364073	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1	0.776
BZW2	EIF6	ENSP00000258761	ENSP00000363559	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity	0.538
BZW2	GINS3	ENSP00000258761	ENSP00000401018	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	GINS complex subunit 3 (Psf3 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA	0.540
BZW2	LZTFL1	ENSP00000258761	ENSP00000296135	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	leucine zipper transcription factor-like 1	0.571
BZW2	PSTPIP1	ENSP00000258761	ENSP00000452746	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	proline-serine-threonine phosphatase interacting protein 1; Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell-APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By simi [...]	0.585
BZW2	UBC	ENSP00000258761	ENSP00000344818	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	ubiquitin C	0.938
CNBP	BZW2	ENSP00000410769	ENSP00000258761	CCHC-type zinc finger, nucleic acid binding protein	basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity)	0.571
CNBP	EIF6	ENSP00000410769	ENSP00000363559	CCHC-type zinc finger, nucleic acid binding protein	eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity	0.583

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