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GLRB GLRB BEST1 BEST1 BEST4 BEST4 ANO1 ANO1 NEDD4 NEDD4 ANO6 ANO6 TTYH3 TTYH3 BEST2 BEST2 BEST3 BEST3 UBC UBC ANO2 ANO2
"TTYH3" - tweety homolog 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TTYH3tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (523 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.951
BEST2
bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (509 aa)
          score_image score_image   0.735
ANO1
anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development (986 aa)
          score_image score_image   0.734
BEST1
bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate (604 aa)
          score_image score_image   0.728
GLRB
glycine receptor, beta; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (497 aa)
          score_image score_image   0.700
ANO2
anoctamin 2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina (998 aa)
          score_image score_image   0.696
BEST3
bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) (668 aa)
          score_image score_image   0.673
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (1247 aa)
        score_image   score_image   0.626
BEST4
bestrophin 4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (473 aa)
          score_image score_image   0.626
ANO6
anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (931 aa)
          score_image score_image   0.603
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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