node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FGF10 | MEF2A | ENSP00000264664 | ENSP00000346389 | fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing | myocyte enhancer factor 2A | 0.580 |
FGF10 | MEF2C | ENSP00000264664 | ENSP00000340874 | fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.598 |
FGF10 | NKX2-8 | ENSP00000264664 | ENSP00000258829 | fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing | NK2 homeobox 8 | 0.602 |
FGF10 | PAX9 | ENSP00000264664 | ENSP00000355245 | fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing | paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) | 0.513 |
FGF17 | MEF2A | ENSP00000352414 | ENSP00000346389 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | myocyte enhancer factor 2A | 0.424 |
FGF17 | MEF2C | ENSP00000352414 | ENSP00000340874 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.431 |
FGF17 | NKX2-8 | ENSP00000352414 | ENSP00000258829 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | NK2 homeobox 8 | 0.601 |
FGF8 | MEF2A | ENSP00000321797 | ENSP00000346389 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | myocyte enhancer factor 2A | 0.597 |
FGF8 | MEF2C | ENSP00000321797 | ENSP00000340874 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.597 |
FGF8 | NKX2-8 | ENSP00000321797 | ENSP00000258829 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | NK2 homeobox 8 | 0.602 |
FGF8 | PAX9 | ENSP00000321797 | ENSP00000355245 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) | 0.923 |
HELZ | NKX2-8 | ENSP00000351524 | ENSP00000258829 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | NK2 homeobox 8 | 0.860 |
HELZ | SMYD3 | ENSP00000351524 | ENSP00000373637 | helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo | SET and MYND domain containing 3; Histone methyltransferase. Specifically methylates ’Lys- 4’ and ’Lys-5’ of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5’-CCCTCC-3’ or 5’-GAGGGG-3’ sequences | 0.936 |
MEF2A | FGF10 | ENSP00000346389 | ENSP00000264664 | myocyte enhancer factor 2A | fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing | 0.580 |
MEF2A | FGF17 | ENSP00000346389 | ENSP00000352414 | myocyte enhancer factor 2A | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | 0.424 |
MEF2A | FGF8 | ENSP00000346389 | ENSP00000321797 | myocyte enhancer factor 2A | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.597 |
MEF2A | MEF2C | ENSP00000346389 | ENSP00000340874 | myocyte enhancer factor 2A | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.904 |
MEF2A | NKX2-8 | ENSP00000346389 | ENSP00000258829 | myocyte enhancer factor 2A | NK2 homeobox 8 | 0.649 |
MEF2B | NKX2-8 | ENSP00000162023 | ENSP00000258829 | myocyte enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription | NK2 homeobox 8 | 0.598 |
MEF2C | FGF10 | ENSP00000340874 | ENSP00000264664 | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing | 0.598 |