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SMYD3 SMYD3 FGF17 FGF17 HELZ HELZ MEF2A MEF2A NKX2-8 NKX2-8 MEF2C MEF2C FGF10 FGF10 MEF2B MEF2B FGF8 FGF8 PAX9 PAX9 SLC25A21 SLC25A21
"NKX2-8" - NK2 homeobox 8 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
NKX2-8NK2 homeobox 8 (239 aa)    
Predicted Functional Partners:
HELZ
helicase with zinc finger; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo (1942 aa)
            score_image   0.860
PAX9
paired box 9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity) (341 aa)
            score_image   0.758
SMYD3
SET and MYND domain containing 3; Histone methyltransferase. Specifically methylates ’Lys- 4’ and ’Lys-5’ of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5’-CCCTCC-3’ or 5’-GAGGGG-3’ sequences (428 aa)
            score_image   0.754
SLC25A21
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate (299 aa)
            score_image   0.658
MEF2A
myocyte enhancer factor 2A (499 aa)
            score_image   0.649
MEF2C
myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] (483 aa)
            score_image   0.632
FGF8
fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (244 aa)
            score_image   0.602
FGF10
fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing (208 aa)
            score_image   0.602
FGF17
fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development (216 aa)
            score_image   0.601
MEF2B
myocyte enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription (368 aa)
            score_image   0.598
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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