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WDR36 WDR36 NAT10 NAT10 TBL3 TBL3 PWP2 PWP2 IMP3 IMP3 MPHOSPH10 MPHOSPH10 NOC4L NOC4L IMP4 IMP4 BRIX1 BRIX1 RRP9 RRP9 MKI67IP MKI67IP
IMP4, U3 small nucleolar ribonucleoprotein, homolog in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
IMP4IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (291 aa)    
Predicted Functional Partners:
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (184 aa)
       score_image score_image   score_image   0.998
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
       score_image score_image   score_image   0.996
RRP9
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast); Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (475 aa)
       score_image score_image   score_image   0.996
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
       score_image score_image       0.994
NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
       score_image score_image   score_image   0.994
PWP2
PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
       score_image score_image   score_image   0.993
BRIX1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit (353 aa)
       score_image score_image   score_image   0.993
WDR36
WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 (951 aa)
       score_image score_image   score_image   0.991
TBL3
transducin (beta)-like 3 (808 aa)
       score_image score_image   score_image   0.991
NAT10
N-acetyltransferase 10 (GCN5-related); Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (1025 aa)
       score_image score_image   score_image   0.991
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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