node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | ALDH1B1 | ENSP00000268251 | ENSP00000366927 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 0.947 |
ABAT | ALDH4A1 | ENSP00000268251 | ENSP00000290597 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 4 family, member A1 | 0.540 |
ABAT | ALDH7A1 | ENSP00000268251 | ENSP00000387123 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 0.945 |
ABAT | ENSG00000257767 | ENSP00000268251 | ENSP00000450353 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | Uncharacterized protein | 0.943 |
ABAT | GAD2 | ENSP00000268251 | ENSP00000259271 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.985 |
ABAT | GLUL | ENSP00000268251 | ENSP00000307900 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.558 |
ALDH1B1 | ABAT | ENSP00000366927 | ENSP00000268251 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | 0.947 |
ALDH1B1 | ALDH4A1 | ENSP00000366927 | ENSP00000290597 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | aldehyde dehydrogenase 4 family, member A1 | 0.838 |
ALDH1B1 | CAD | ENSP00000366927 | ENSP00000264705 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.883 |
ALDH1B1 | GAD2 | ENSP00000366927 | ENSP00000259271 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.924 |
ALDH4A1 | ABAT | ENSP00000290597 | ENSP00000268251 | aldehyde dehydrogenase 4 family, member A1 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | 0.540 |
ALDH4A1 | ALDH1B1 | ENSP00000290597 | ENSP00000366927 | aldehyde dehydrogenase 4 family, member A1 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 0.838 |
ALDH4A1 | ALDH7A1 | ENSP00000290597 | ENSP00000387123 | aldehyde dehydrogenase 4 family, member A1 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 0.852 |
ALDH4A1 | CAD | ENSP00000290597 | ENSP00000264705 | aldehyde dehydrogenase 4 family, member A1 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.883 |
ALDH4A1 | ENSG00000257767 | ENSP00000290597 | ENSP00000450353 | aldehyde dehydrogenase 4 family, member A1 | Uncharacterized protein | 0.801 |
ALDH4A1 | GAD2 | ENSP00000290597 | ENSP00000259271 | aldehyde dehydrogenase 4 family, member A1 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.928 |
ALDH4A1 | GLS | ENSP00000290597 | ENSP00000317379 | aldehyde dehydrogenase 4 family, member A1 | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.914 |
ALDH4A1 | GLUL | ENSP00000290597 | ENSP00000307900 | aldehyde dehydrogenase 4 family, member A1 | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.945 |
ALDH7A1 | ABAT | ENSP00000387123 | ENSP00000268251 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | 0.945 |
ALDH7A1 | ALDH4A1 | ENSP00000387123 | ENSP00000290597 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | aldehyde dehydrogenase 4 family, member A1 | 0.852 |