| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HIST1H2BB | TOR1B | ENSP00000350580 | ENSP00000259339 | histone cluster 1, H2bb; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | torsin family 1, member B (torsin B); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (By similarity) | 0.533 |
| HLA-DQB1 | TNFRSF21 | ENSP00000382034 | ENSP00000296861 | major histocompatibility complex, class II, DQ beta 1 | tumor necrosis factor receptor superfamily, member 21; May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) | 0.471 |
| HLA-DQB1 | TNFRSF25 | ENSP00000382034 | ENSP00000367013 | major histocompatibility complex, class II, DQ beta 1 | tumor necrosis factor receptor superfamily, member 25 | 0.729 |
| HLA-DQB1 | TOR1A | ENSP00000382034 | ENSP00000345719 | major histocompatibility complex, class II, DQ beta 1 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.824 |
| HLA-DQB1 | TOR1B | ENSP00000382034 | ENSP00000259339 | major histocompatibility complex, class II, DQ beta 1 | torsin family 1, member B (torsin B); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (By similarity) | 0.636 |
| NISCH | TOR1B | ENSP00000339958 | ENSP00000259339 | nischarin | torsin family 1, member B (torsin B); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (By similarity) | 0.513 |
| NKX2-1 | TOR1A | ENSP00000346879 | ENSP00000345719 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.794 |
| NKX2-1 | TOR1B | ENSP00000346879 | ENSP00000259339 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | torsin family 1, member B (torsin B); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (By similarity) | 0.599 |
| NKX2-4 | TOR1A | ENSP00000345147 | ENSP00000345719 | NK2 homeobox 4; Probable transcription factor | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.599 |
| NKX2-4 | TOR1B | ENSP00000345147 | ENSP00000259339 | NK2 homeobox 4; Probable transcription factor | torsin family 1, member B (torsin B); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (By similarity) | 0.599 |
| TNFRSF21 | HLA-DQB1 | ENSP00000296861 | ENSP00000382034 | tumor necrosis factor receptor superfamily, member 21; May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) | major histocompatibility complex, class II, DQ beta 1 | 0.471 |
| TNFRSF21 | TNFRSF25 | ENSP00000296861 | ENSP00000367013 | tumor necrosis factor receptor superfamily, member 21; May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) | tumor necrosis factor receptor superfamily, member 25 | 0.720 |
| TNFRSF21 | TOR1B | ENSP00000296861 | ENSP00000259339 | tumor necrosis factor receptor superfamily, member 21; May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) | torsin family 1, member B (torsin B); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (By similarity) | 0.589 |
| TNFRSF25 | HLA-DQB1 | ENSP00000367013 | ENSP00000382034 | tumor necrosis factor receptor superfamily, member 25 | major histocompatibility complex, class II, DQ beta 1 | 0.729 |
| TNFRSF25 | TNFRSF21 | ENSP00000367013 | ENSP00000296861 | tumor necrosis factor receptor superfamily, member 25 | tumor necrosis factor receptor superfamily, member 21; May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) | 0.720 |
| TNFRSF25 | TOR1A | ENSP00000367013 | ENSP00000345719 | tumor necrosis factor receptor superfamily, member 25 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.871 |
| TNFRSF25 | TOR1B | ENSP00000367013 | ENSP00000259339 | tumor necrosis factor receptor superfamily, member 25 | torsin family 1, member B (torsin B); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (By similarity) | 0.588 |
| TOR1A | HLA-DQB1 | ENSP00000345719 | ENSP00000382034 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | major histocompatibility complex, class II, DQ beta 1 | 0.824 |
| TOR1A | NKX2-1 | ENSP00000345719 | ENSP00000346879 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | 0.794 |
| TOR1A | NKX2-4 | ENSP00000345719 | ENSP00000345147 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | NK2 homeobox 4; Probable transcription factor | 0.599 |
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