node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYH6 | NEB | ENSP00000348634 | ENSP00000380505 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | nebulin | 0.930 |
MYH6 | TMOD1 | ENSP00000348634 | ENSP00000259365 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomodulin 1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus | 0.926 |
MYH6 | TNNC2 | ENSP00000348634 | ENSP00000361636 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.970 |
MYH6 | TNNT2 | ENSP00000348634 | ENSP00000356286 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.987 |
MYH6 | TNNT3 | ENSP00000348634 | ENSP00000278317 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin T type 3 (skeletal, fast) | 0.976 |
MYH6 | TPM1 | ENSP00000348634 | ENSP00000267996 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 1 (alpha) | 0.986 |
MYH6 | TPM2 | ENSP00000348634 | ENSP00000354219 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.973 |
MYH6 | TPM3 | ENSP00000348634 | ENSP00000357516 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments | 0.986 |
MYH6 | TPM4 | ENSP00000348634 | ENSP00000345230 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 4 | 0.961 |
MYH6 | TTN | ENSP00000348634 | ENSP00000343764 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | titin | 0.971 |
NEB | MYH6 | ENSP00000380505 | ENSP00000348634 | nebulin | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.930 |
NEB | TMOD1 | ENSP00000380505 | ENSP00000259365 | nebulin | tropomodulin 1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus | 0.977 |
NEB | TNNC2 | ENSP00000380505 | ENSP00000361636 | nebulin | troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.929 |
NEB | TNNT2 | ENSP00000380505 | ENSP00000356286 | nebulin | troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.922 |
NEB | TNNT3 | ENSP00000380505 | ENSP00000278317 | nebulin | troponin T type 3 (skeletal, fast) | 0.934 |
NEB | TPM1 | ENSP00000380505 | ENSP00000267996 | nebulin | tropomyosin 1 (alpha) | 0.933 |
NEB | TPM2 | ENSP00000380505 | ENSP00000354219 | nebulin | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.954 |
NEB | TPM3 | ENSP00000380505 | ENSP00000357516 | nebulin | tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments | 0.949 |
NEB | TPM4 | ENSP00000380505 | ENSP00000345230 | nebulin | tropomyosin 4 | 0.907 |
NEB | TTN | ENSP00000380505 | ENSP00000343764 | nebulin | titin | 0.999 |