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STRINGSTRING
TECTB TECTB LTN1 LTN1 UBE2D2 UBE2D2 TP53 TP53 RNF14 RNF14 RNF38 RNF38 GNE GNE UBC UBC LDB1 LDB1 CLTB CLTB CLTA CLTA
"RNF38" - ring finger protein 38 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
RNF38ring finger protein 38 (515 aa)    
Predicted Functional Partners:
GNE
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (753 aa)
            score_image   0.869
UBE2D2
ubiquitin-conjugating enzyme E2D 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’-, as well as ’Lys-48’-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions ’Lys-21’ and/or ’Lys-22’ with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-prime [...] (147 aa)
        score_image   score_image   0.689
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (393 aa)
        score_image       0.688
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.678
LDB1
LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) (411 aa)
        score_image   score_image   0.589
LTN1
listerin E3 ubiquitin protein ligase 1 (1812 aa)
            score_image   0.576
RNF14
ring finger protein 14 (474 aa)
            score_image   0.572
CLTA
clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (248 aa)
            score_image   0.513
CLTB
clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (229 aa)
            score_image   0.499
TECTB
tectorin beta; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals (329 aa)
            score_image   0.469
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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