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TBC1D9 TBC1D9 TBC1D8B TBC1D8B TBC1D9B TBC1D9B CHL1 CHL1 FAM65B FAM65B TBC1D8 TBC1D8 MYOG MYOG RHOA RHOA MYOD1 MYOD1 RHOC RHOC C9orf171 C9orf171
"FAM65B" - family with sequence similarity 65, member B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FAM65Bfamily with sequence similarity 65, member B; Isoform 2 play a role in promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation (1068 aa)    
Predicted Functional Partners:
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1); Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dep [...] (1224 aa)
            score_image   0.800
RHOA
ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] (193 aa)
        score_image       0.623
RHOC
ras homolog family member C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (193 aa)
        score_image       0.612
MYOG
myogenin (myogenic factor 4); Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (224 aa)
            score_image   0.583
MYOD1
myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) (320 aa)
            score_image   0.493
TBC1D9
TBC1 domain family, member 9 (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1266 aa)
            score_image   0.485
TBC1D8
TBC1 domain family, member 8 (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1140 aa)
            score_image   0.485
TBC1D8B
TBC1 domain family, member 8B (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1120 aa)
            score_image   0.485
TBC1D9B
TBC1 domain family, member 9B (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1250 aa)
            score_image   0.485
C9orf171
chromosome 9 open reading frame 171 (320 aa)
            score_image   0.450
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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