TTBK1 protein (Homo sapiens) - STRING network view

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TTBK1

tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (1321 aa)

Predicted Functional Partners:

MAPT

0.864

GRIN2B

0.831

RIOK2

0.794

RPS3

0.776

BYSL

0.746

TSR1

0.705

TUBB2A

0.634

ELP3

0.622

CDK5R1

0.598

PCDHGB4

0.596

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BYSL	ELP3	ENSP00000230340	ENSP00000256398	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	elongator acetyltransferase complex subunit 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration	0.435
BYSL	RIOK2	ENSP00000230340	ENSP00000283109	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	RIO kinase 2 (yeast)	0.989
BYSL	RPS3	ENSP00000230340	ENSP00000433821	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	ribosomal protein S3	0.984
BYSL	TSR1	ENSP00000230340	ENSP00000301364	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.999
BYSL	TTBK1	ENSP00000230340	ENSP00000259750	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.746
CDK5R1	TTBK1	ENSP00000318486	ENSP00000259750	cyclin-dependent kinase 5, regulatory subunit 1 (p35); p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.598
ELP3	BYSL	ENSP00000256398	ENSP00000230340	elongator acetyltransferase complex subunit 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	0.435
ELP3	TTBK1	ENSP00000256398	ENSP00000259750	elongator acetyltransferase complex subunit 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.622
GRIN2B	TTBK1	ENSP00000279593	ENSP00000259750	glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity)	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.831
MAPT	TTBK1	ENSP00000340820	ENSP00000259750	microtubule-associated protein tau	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.864
MAPT	TUBB2A	ENSP00000340820	ENSP00000369703	microtubule-associated protein tau	tubulin, beta 2A class IIa; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.647
PCDHGB4	TTBK1	ENSP00000428288	ENSP00000259750	protocadherin gamma subfamily B, 4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.596
RIOK2	BYSL	ENSP00000283109	ENSP00000230340	RIO kinase 2 (yeast)	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	0.989
RIOK2	RPS3	ENSP00000283109	ENSP00000433821	RIO kinase 2 (yeast)	ribosomal protein S3	0.637
RIOK2	TSR1	ENSP00000283109	ENSP00000301364	RIO kinase 2 (yeast)	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.999
RIOK2	TTBK1	ENSP00000283109	ENSP00000259750	RIO kinase 2 (yeast)	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.794
RPS3	BYSL	ENSP00000433821	ENSP00000230340	ribosomal protein S3	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	0.984
RPS3	RIOK2	ENSP00000433821	ENSP00000283109	ribosomal protein S3	RIO kinase 2 (yeast)	0.637
RPS3	TSR1	ENSP00000433821	ENSP00000301364	ribosomal protein S3	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.692
RPS3	TTBK1	ENSP00000433821	ENSP00000259750	ribosomal protein S3	tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU	0.776

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