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STRINGSTRING
MCL1 MCL1 MAPK1 MAPK1 TNFSF10 TNFSF10 BIRC2 BIRC2 PPP2R5B PPP2R5B PPP2R5C PPP2R5C PPP2R4 PPP2R4 IER3 IER3 GGNBP2 GGNBP2 SLC37A2 SLC37A2 SLC15A3 SLC15A3
"IER3" - immediate early response 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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IER3immediate early response 3; May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment (156 aa)    
Predicted Functional Partners:
MAPK1
mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] (360 aa)
        score_image   score_image   0.818
MCL1
myeloid cell leukemia sequence 1 (BCL2-related) (350 aa)
        score_image   score_image   0.660
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10; Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis (281 aa)
        score_image   score_image   0.655
PPP2R5B
protein phosphatase 2, regulatory subunit B’, beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the ’Thr-308’ and ’Ser-373’ residues (497 aa)
        score_image   score_image   0.649
GGNBP2
gametogenetin binding protein 2; May be involved in spermatogenesis (697 aa)
            score_image   0.636
PPP2R5C
protein phosphatase 2, regulatory subunit B’, gamma; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (555 aa)
        score_image   score_image   0.607
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4 (323 aa)
        score_image   score_image   0.600
BIRC2
baculoviral IAP repeat containing 2; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions- acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for it [...] (618 aa)
            score_image   0.593
SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2 (505 aa)
            score_image   0.593
SLC15A3
solute carrier family 15, member 3; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity) (581 aa)
            score_image   0.593
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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