PI15 protein (Homo sapiens) - STRING network view

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PI15

peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (258 aa)

Predicted Functional Partners:

ZG16

0.670

SSNA1

0.669

ISM1

0.619

GLIPR2

0.598

RPGR

0.596

ENPEP

0.575

ADAMTS16

0.562

EFTUD1

0.526

CREB3L1

0.499

SERPINB13

0.472

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS16	CREB3L1	ENSP00000274181	ENSP00000434939	ADAM metallopeptidase with thrombospondin type 1 motif, 16	cAMP responsive element binding protein 3-like 1; Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)	0.438
ADAMTS16	ENPEP	ENSP00000274181	ENSP00000265162	ADAM metallopeptidase with thrombospondin type 1 motif, 16	glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells	0.461
ADAMTS16	PI15	ENSP00000274181	ENSP00000260113	ADAM metallopeptidase with thrombospondin type 1 motif, 16	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	0.562
CREB3L1	ADAMTS16	ENSP00000434939	ENSP00000274181	cAMP responsive element binding protein 3-like 1; Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)	ADAM metallopeptidase with thrombospondin type 1 motif, 16	0.438
CREB3L1	PI15	ENSP00000434939	ENSP00000260113	cAMP responsive element binding protein 3-like 1; Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	0.499
EFTUD1	PI15	ENSP00000268206	ENSP00000260113	elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	0.526
ENPEP	ADAMTS16	ENSP00000265162	ENSP00000274181	glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells	ADAM metallopeptidase with thrombospondin type 1 motif, 16	0.461
ENPEP	PI15	ENSP00000265162	ENSP00000260113	glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	0.575
GLIPR2	PI15	ENSP00000367196	ENSP00000260113	GLI pathogenesis-related 2	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	0.598
ISM1	PI15	ENSP00000262487	ENSP00000260113	isthmin 1 homolog (zebrafish)	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	0.619
PI15	ADAMTS16	ENSP00000260113	ENSP00000274181	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	ADAM metallopeptidase with thrombospondin type 1 motif, 16	0.562
PI15	CREB3L1	ENSP00000260113	ENSP00000434939	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	cAMP responsive element binding protein 3-like 1; Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)	0.499
PI15	EFTUD1	ENSP00000260113	ENSP00000268206	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits	0.526
PI15	ENPEP	ENSP00000260113	ENSP00000265162	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells	0.575
PI15	GLIPR2	ENSP00000260113	ENSP00000367196	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	GLI pathogenesis-related 2	0.598
PI15	ISM1	ENSP00000260113	ENSP00000262487	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	isthmin 1 homolog (zebrafish)	0.619
PI15	RPGR	ENSP00000260113	ENSP00000367766	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	retinitis pigmentosa GTPase regulator	0.596
PI15	SERPINB13	ENSP00000260113	ENSP00000341584	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	serpin peptidase inhibitor, clade B (ovalbumin), member 13; May play a role in the proliferation or differentiation of keratinocytes	0.472
PI15	SSNA1	ENSP00000260113	ENSP00000313752	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	Sjogren syndrome nuclear autoantigen 1	0.669
PI15	ZG16	ENSP00000260113	ENSP00000383563	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.670

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