| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATCAY | TTPA | ENSP00000390941 | ENSP00000260116 | ataxia, cerebellar, Cayman type; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.812 |
| BNIP2 | TTPA | ENSP00000267859 | ENSP00000260116 | BCL2/adenovirus E1B 19kDa interacting protein 2; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.678 |
| C10orf2 | EIF3K | ENSP00000309595 | ENSP00000248342 | chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals | eukaryotic translation initiation factor 3, subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.414 |
| C10orf2 | FXN | ENSP00000309595 | ENSP00000366482 | chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | 0.610 |
| C10orf2 | SLC6A11 | ENSP00000309595 | ENSP00000254488 | chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals | solute carrier family 6 (neurotransmitter transporter, GABA), member 11; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.740 |
| C10orf2 | TTPA | ENSP00000309595 | ENSP00000260116 | chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.757 |
| EIF3K | C10orf2 | ENSP00000248342 | ENSP00000309595 | eukaryotic translation initiation factor 3, subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals | 0.414 |
| EIF3K | PRUNE2 | ENSP00000248342 | ENSP00000365908 | eukaryotic translation initiation factor 3, subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | prune homolog 2 (Drosophila) | 0.489 |
| EIF3K | TTPA | ENSP00000248342 | ENSP00000260116 | eukaryotic translation initiation factor 3, subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.610 |
| F2 | TTPA | ENSP00000308541 | ENSP00000260116 | coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.659 |
| F2 | YARS | ENSP00000308541 | ENSP00000362576 | coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.593 |
| FXN | C10orf2 | ENSP00000366482 | ENSP00000309595 | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals | 0.610 |
| FXN | TTPA | ENSP00000366482 | ENSP00000260116 | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.688 |
| PRUNE2 | EIF3K | ENSP00000365908 | ENSP00000248342 | prune homolog 2 (Drosophila) | eukaryotic translation initiation factor 3, subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.489 |
| PRUNE2 | TTPA | ENSP00000365908 | ENSP00000260116 | prune homolog 2 (Drosophila) | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.752 |
| RRS1 | TTPA | ENSP00000322396 | ENSP00000260116 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); Involved in ribosome biogenesis (By similarity) | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.703 |
| SLC6A11 | C10orf2 | ENSP00000254488 | ENSP00000309595 | solute carrier family 6 (neurotransmitter transporter, GABA), member 11; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals | chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals | 0.740 |
| SLC6A11 | TTPA | ENSP00000254488 | ENSP00000260116 | solute carrier family 6 (neurotransmitter transporter, GABA), member 11; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | 0.685 |
| TTPA | ATCAY | ENSP00000260116 | ENSP00000390941 | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | ataxia, cerebellar, Cayman type; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites | 0.812 |
| TTPA | BNIP2 | ENSP00000260116 | ENSP00000267859 | tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes | BCL2/adenovirus E1B 19kDa interacting protein 2; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins | 0.678 |
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