BUD13 protein (Homo sapiens) - STRING network view

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Score

BUD13

BUD13 homolog (S. cerevisiae) (619 aa)

Predicted Functional Partners:

RBMX2

0.999

SF3B1

0.979

SF3B2

0.974

PRPF19

0.973

U2AF2

0.965

CDC5L

0.965

SF1

0.956

MFAP1

0.956

UBL5

0.951

RNF113A

0.949

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUD13	CDC5L	ENSP00000260210	ENSP00000360532	BUD13 homolog (S. cerevisiae)	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	0.965
BUD13	MFAP1	ENSP00000260210	ENSP00000267812	BUD13 homolog (S. cerevisiae)	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.956
BUD13	PRPF19	ENSP00000260210	ENSP00000227524	BUD13 homolog (S. cerevisiae)	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.973
BUD13	RBMX2	ENSP00000260210	ENSP00000339090	BUD13 homolog (S. cerevisiae)	RNA binding motif protein, X-linked 2	0.999
BUD13	RNF113A	ENSP00000260210	ENSP00000360497	BUD13 homolog (S. cerevisiae)	ring finger protein 113A	0.949
BUD13	SF1	ENSP00000260210	ENSP00000366604	BUD13 homolog (S. cerevisiae)	splicing factor 1	0.956
BUD13	SF3B1	ENSP00000260210	ENSP00000335321	BUD13 homolog (S. cerevisiae)	splicing factor 3b, subunit 1, 155kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	0.979
BUD13	SF3B2	ENSP00000260210	ENSP00000318861	BUD13 homolog (S. cerevisiae)	splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	0.974
BUD13	U2AF2	ENSP00000260210	ENSP00000307863	BUD13 homolog (S. cerevisiae)	U2 small nuclear RNA auxiliary factor 2; Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10	0.965
BUD13	UBL5	ENSP00000260210	ENSP00000351492	BUD13 homolog (S. cerevisiae)	ubiquitin-like 5	0.951
CDC5L	BUD13	ENSP00000360532	ENSP00000260210	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	BUD13 homolog (S. cerevisiae)	0.965
CDC5L	PRPF19	ENSP00000360532	ENSP00000227524	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.999
CDC5L	RBMX2	ENSP00000360532	ENSP00000339090	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	RNA binding motif protein, X-linked 2	0.962
CDC5L	RNF113A	ENSP00000360532	ENSP00000360497	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	ring finger protein 113A	0.917
CDC5L	SF3B1	ENSP00000360532	ENSP00000335321	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	splicing factor 3b, subunit 1, 155kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	0.996
CDC5L	SF3B2	ENSP00000360532	ENSP00000318861	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	0.996
CDC5L	U2AF2	ENSP00000360532	ENSP00000307863	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	U2 small nuclear RNA auxiliary factor 2; Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10	0.920
MFAP1	BUD13	ENSP00000267812	ENSP00000260210	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	BUD13 homolog (S. cerevisiae)	0.956
MFAP1	PRPF19	ENSP00000267812	ENSP00000227524	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.903
MFAP1	RBMX2	ENSP00000267812	ENSP00000339090	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	RNA binding motif protein, X-linked 2	0.987

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