| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSNK2A1 | CSNK2A2 | ENSP00000217244 | ENSP00000262506 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | 0.788 |
| CSNK2A1 | HCFC2 | ENSP00000217244 | ENSP00000229330 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | host cell factor C2 | 0.800 |
| CSNK2A1 | POU2F3 | ENSP00000217244 | ENSP00000260264 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.800 |
| CSNK2A2 | CSNK2A1 | ENSP00000262506 | ENSP00000217244 | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.788 |
| CSNK2A2 | HCFC2 | ENSP00000262506 | ENSP00000229330 | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | host cell factor C2 | 0.800 |
| CSNK2A2 | POU2F3 | ENSP00000262506 | ENSP00000260264 | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.800 |
| DCAF11 | POU2F3 | ENSP00000415556 | ENSP00000260264 | DDB1 and CUL4 associated factor 11 | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.860 |
| ELF3 | POU2F3 | ENSP00000352673 | ENSP00000260264 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ); Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. [...] | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.680 |
| ELF3 | SPRR2A | ENSP00000352673 | ENSP00000376423 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ); Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. [...] | small proline-rich protein 2A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane | 0.666 |
| HCFC2 | CSNK2A1 | ENSP00000229330 | ENSP00000217244 | host cell factor C2 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.800 |
| HCFC2 | CSNK2A2 | ENSP00000229330 | ENSP00000262506 | host cell factor C2 | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | 0.800 |
| HCFC2 | POU2F3 | ENSP00000229330 | ENSP00000260264 | host cell factor C2 | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.800 |
| ITGB3 | POU2F3 | ENSP00000262017 | ENSP00000260264 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.813 |
| LIPG | POU2F3 | ENSP00000261292 | ENSP00000260264 | lipase, endothelial; Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.758 |
| LOR | POU2F3 | ENSP00000357731 | ENSP00000260264 | loricrin; Major keratinocyte cell envelope protein | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.864 |
| PLA1A | POU2F3 | ENSP00000273371 | ENSP00000260264 | phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | 0.745 |
| POU2F3 | CSNK2A1 | ENSP00000260264 | ENSP00000217244 | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.800 |
| POU2F3 | CSNK2A2 | ENSP00000260264 | ENSP00000262506 | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | 0.800 |
| POU2F3 | DCAF11 | ENSP00000260264 | ENSP00000415556 | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | DDB1 and CUL4 associated factor 11 | 0.860 |
| POU2F3 | ELF3 | ENSP00000260264 | ENSP00000352673 | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen | E74-like factor 3 (ets domain transcription factor, epithelial-specific ); Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. [...] | 0.680 |
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