node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR | AKAP13 | ENSP00000303909 | ENSP00000354718 | active BCR-related | A kinase (PRKA) anchor protein 13 | 0.917 |
ABR | ARHGAP20 | ENSP00000303909 | ENSP00000260283 | active BCR-related | Rho GTPase activating protein 20 | 0.920 |
ABR | ARHGEF11 | ENSP00000303909 | ENSP00000357177 | active BCR-related | Rho guanine nucleotide exchange factor (GEF) 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.901 |
ABR | ARHGEF12 | ENSP00000303909 | ENSP00000380942 | active BCR-related | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.906 |
ABR | CDC42 | ENSP00000303909 | ENSP00000314458 | active BCR-related | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.929 |
ABR | MCF2L | ENSP00000303909 | ENSP00000440374 | active BCR-related | MCF.2 cell line derived transforming sequence-like | 0.907 |
ABR | PLEKHG5 | ENSP00000303909 | ENSP00000366977 | active BCR-related | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | 0.900 |
ABR | RHOA | ENSP00000303909 | ENSP00000400175 | active BCR-related | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.919 |
ABR | TIAM1 | ENSP00000303909 | ENSP00000286827 | active BCR-related | T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA | 0.922 |
ABR | TIAM2 | ENSP00000303909 | ENSP00000327315 | active BCR-related | T-cell lymphoma invasion and metastasis 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by [...] | 0.905 |
AKAP13 | ABR | ENSP00000354718 | ENSP00000303909 | A kinase (PRKA) anchor protein 13 | active BCR-related | 0.917 |
AKAP13 | ARHGAP20 | ENSP00000354718 | ENSP00000260283 | A kinase (PRKA) anchor protein 13 | Rho GTPase activating protein 20 | 0.914 |
AKAP13 | ARHGEF12 | ENSP00000354718 | ENSP00000380942 | A kinase (PRKA) anchor protein 13 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.917 |
AKAP13 | CDC42 | ENSP00000354718 | ENSP00000314458 | A kinase (PRKA) anchor protein 13 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.961 |
AKAP13 | RHOA | ENSP00000354718 | ENSP00000400175 | A kinase (PRKA) anchor protein 13 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.999 |
ARHGAP20 | ABR | ENSP00000260283 | ENSP00000303909 | Rho GTPase activating protein 20 | active BCR-related | 0.920 |
ARHGAP20 | AKAP13 | ENSP00000260283 | ENSP00000354718 | Rho GTPase activating protein 20 | A kinase (PRKA) anchor protein 13 | 0.914 |
ARHGAP20 | ARHGEF11 | ENSP00000260283 | ENSP00000357177 | Rho GTPase activating protein 20 | Rho guanine nucleotide exchange factor (GEF) 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.919 |
ARHGAP20 | ARHGEF12 | ENSP00000260283 | ENSP00000380942 | Rho GTPase activating protein 20 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.917 |
ARHGAP20 | CDC42 | ENSP00000260283 | ENSP00000314458 | Rho GTPase activating protein 20 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.920 |