CTDSPL2 protein (Homo sapiens) - STRING network view

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CTDSPL2

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity) (466 aa)

Predicted Functional Partners:

UBC

0.696

USP38

0.661

QRSL1

0.657

WDFY1

0.655

BLOC1S6

0.655

TRIP4

0.637

OBSCN

0.624

WDFY2

0.585

PRPSAP2

0.564

GTF2F1

0.526

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLOC1S6	CTDSPL2	ENSP00000220531	ENSP00000260327	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, partic [...]	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	0.655
CTDSPL2	BLOC1S6	ENSP00000260327	ENSP00000220531	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, partic [...]	0.655
CTDSPL2	GTF2F1	ENSP00000260327	ENSP00000377969	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	general transcription factor IIF, polypeptide 1, 74kDa; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation	0.526
CTDSPL2	OBSCN	ENSP00000260327	ENSP00000455507	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.624
CTDSPL2	PRPSAP2	ENSP00000260327	ENSP00000268835	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis	0.564
CTDSPL2	QRSL1	ENSP00000260327	ENSP00000358042	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)	0.657
CTDSPL2	TRIP4	ENSP00000260327	ENSP00000261884	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	thyroid hormone receptor interactor 4; Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity)	0.637
CTDSPL2	UBC	ENSP00000260327	ENSP00000344818	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	ubiquitin C	0.696
CTDSPL2	USP38	ENSP00000260327	ENSP00000303434	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	ubiquitin specific peptidase 38; Deubiquitinating enzyme exhibiting a preference towards ’Lys-63’-linked Ubiquitin chains	0.661
CTDSPL2	WDFY1	ENSP00000260327	ENSP00000233055	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	WD repeat and FYVE domain containing 1	0.655
CTDSPL2	WDFY2	ENSP00000260327	ENSP00000298125	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	WD repeat and FYVE domain containing 2	0.585
GTF2F1	CTDSPL2	ENSP00000377969	ENSP00000260327	general transcription factor IIF, polypeptide 1, 74kDa; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	0.526
GTF2F1	UBC	ENSP00000377969	ENSP00000344818	general transcription factor IIF, polypeptide 1, 74kDa; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation	ubiquitin C	0.868
OBSCN	CTDSPL2	ENSP00000455507	ENSP00000260327	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	0.624
PRPSAP2	CTDSPL2	ENSP00000268835	ENSP00000260327	phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; Probable phosphatase (By similarity)	0.564
PRPSAP2	QRSL1	ENSP00000268835	ENSP00000358042	phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)	0.530
PRPSAP2	TRIP4	ENSP00000268835	ENSP00000261884	phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis	thyroid hormone receptor interactor 4; Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity)	0.478
PRPSAP2	UBC	ENSP00000268835	ENSP00000344818	phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis	ubiquitin C	0.818
PRPSAP2	USP38	ENSP00000268835	ENSP00000303434	phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis	ubiquitin specific peptidase 38; Deubiquitinating enzyme exhibiting a preference towards ’Lys-63’-linked Ubiquitin chains	0.531
PRPSAP2	WDFY1	ENSP00000268835	ENSP00000233055	phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis	WD repeat and FYVE domain containing 1	0.571

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