node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMS1 | BRIX1 | ENSP00000363642 | ENSP00000338862 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | 0.848 |
BMS1 | BYSL | ENSP00000363642 | ENSP00000230340 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos | 0.995 |
BMS1 | CIRH1A | ENSP00000363642 | ENSP00000327179 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | 0.979 |
BMS1 | IMP4 | ENSP00000363642 | ENSP00000259239 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing | 0.905 |
BMS1 | NOC4L | ENSP00000363642 | ENSP00000328854 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | nucleolar complex associated 4 homolog (S. cerevisiae) | 0.985 |
BMS1 | NOP14 | ENSP00000363642 | ENSP00000315674 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity) | 0.999 |
BMS1 | RRP9 | ENSP00000363642 | ENSP00000232888 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast); Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA | 0.996 |
BMS1 | RTCA | ENSP00000363642 | ENSP00000260563 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | RNA 3’-terminal phosphate cyclase; Catalyzes the conversion of 3’-phosphate to a 2’,3’- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps- (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3’P to produce RNA- N3’PP5’A; (C) and attack of the adjacent 2’-hydroxyl on the 3’- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing | 0.967 |
BMS1 | UTP15 | ENSP00000363642 | ENSP00000296792 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) | 0.974 |
BMS1 | WDR12 | ENSP00000363642 | ENSP00000261015 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.748 |
BRIX1 | BMS1 | ENSP00000338862 | ENSP00000363642 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | 0.848 |
BRIX1 | BYSL | ENSP00000338862 | ENSP00000230340 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos | 0.960 |
BRIX1 | CIRH1A | ENSP00000338862 | ENSP00000327179 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | 0.886 |
BRIX1 | IMP4 | ENSP00000338862 | ENSP00000259239 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing | 0.993 |
BRIX1 | NOC4L | ENSP00000338862 | ENSP00000328854 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | nucleolar complex associated 4 homolog (S. cerevisiae) | 0.931 |
BRIX1 | NOP14 | ENSP00000338862 | ENSP00000315674 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity) | 0.818 |
BRIX1 | RRP9 | ENSP00000338862 | ENSP00000232888 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast); Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA | 0.722 |
BRIX1 | RTCA | ENSP00000338862 | ENSP00000260563 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | RNA 3’-terminal phosphate cyclase; Catalyzes the conversion of 3’-phosphate to a 2’,3’- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps- (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3’P to produce RNA- N3’PP5’A; (C) and attack of the adjacent 2’-hydroxyl on the 3’- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing | 0.931 |
BRIX1 | UTP15 | ENSP00000338862 | ENSP00000296792 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) | 0.956 |
BRIX1 | WDR12 | ENSP00000338862 | ENSP00000261015 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.998 |