node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY3 | PDE2A | ENSP00000260600 | ENSP00000334910 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | 0.963 |
ADCY3 | PDE4A | ENSP00000260600 | ENSP00000270474 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 4A, cAMP-specific | 0.967 |
ADCY3 | PDE4B | ENSP00000260600 | ENSP00000332116 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents | 0.966 |
ADCY3 | PDE6B | ENSP00000260600 | ENSP00000420295 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.964 |
ADCY3 | PDE7A | ENSP00000260600 | ENSP00000385632 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction | 0.964 |
ADCY3 | PDE7B | ENSP00000260600 | ENSP00000310661 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 7B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain | 0.967 |
ADCY3 | PRKAR1A | ENSP00000260600 | ENSP00000351410 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.968 |
ADCY3 | PRKAR1B | ENSP00000260600 | ENSP00000353415 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.969 |
ADCY3 | PRKAR2A | ENSP00000260600 | ENSP00000265563 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.966 |
ADCY3 | PRKAR2B | ENSP00000260600 | ENSP00000265717 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.968 |
PDE2A | ADCY3 | ENSP00000334910 | ENSP00000260600 | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.963 |
PDE2A | PRKAR1A | ENSP00000334910 | ENSP00000351410 | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.601 |
PDE2A | PRKAR1B | ENSP00000334910 | ENSP00000353415 | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.583 |
PDE2A | PRKAR2A | ENSP00000334910 | ENSP00000265563 | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.599 |
PDE2A | PRKAR2B | ENSP00000334910 | ENSP00000265717 | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.615 |
PDE4A | ADCY3 | ENSP00000270474 | ENSP00000260600 | phosphodiesterase 4A, cAMP-specific | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.967 |
PDE4A | PDE4B | ENSP00000270474 | ENSP00000332116 | phosphodiesterase 4A, cAMP-specific | phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents | 0.902 |
PDE4A | PRKAR1A | ENSP00000270474 | ENSP00000351410 | phosphodiesterase 4A, cAMP-specific | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.655 |
PDE4A | PRKAR1B | ENSP00000270474 | ENSP00000353415 | phosphodiesterase 4A, cAMP-specific | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.658 |
PDE4A | PRKAR2A | ENSP00000270474 | ENSP00000265563 | phosphodiesterase 4A, cAMP-specific | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.831 |