PREPL protein (Homo sapiens) - STRING network view

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Score

PREPL

prolyl endopeptidase-like (727 aa)

Predicted Functional Partners:

CAMKMT

0.881

PPM1B

0.864

SLC3A1

0.860

UBC

0.849

USP22

0.740

ENSG00000269547

0.712

LAP3

0.676

APEH

0.655

F10

0.653

PACRG

0.623

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEH	LAP3	ENSP00000296456	ENSP00000226299	N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	0.498
APEH	PREPL	ENSP00000296456	ENSP00000260648	N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser	prolyl endopeptidase-like	0.655
APEH	UBC	ENSP00000296456	ENSP00000344818	N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser	ubiquitin C	0.964
CAMKMT	ENSG00000269547	ENSP00000367755	ENSP00000472465	calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin	F-box only protein 17	0.674
CAMKMT	PACRG	ENSP00000367755	ENSP00000337946	calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin	PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease	0.549
CAMKMT	PPM1B	ENSP00000367755	ENSP00000282412	calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin	protein phosphatase, Mg2+/Mn2+ dependent, 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro	0.868
CAMKMT	PREPL	ENSP00000367755	ENSP00000260648	calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin	prolyl endopeptidase-like	0.881
CAMKMT	SLC3A1	ENSP00000367755	ENSP00000260649	calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin	solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule	0.862
ENSG00000269547	CAMKMT	ENSP00000472465	ENSP00000367755	F-box only protein 17	calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin	0.674
ENSG00000269547	PREPL	ENSP00000472465	ENSP00000260648	F-box only protein 17	prolyl endopeptidase-like	0.712
F10	PPM1B	ENSP00000364709	ENSP00000282412	coagulation factor X; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting	protein phosphatase, Mg2+/Mn2+ dependent, 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro	0.606
F10	PREPL	ENSP00000364709	ENSP00000260648	coagulation factor X; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting	prolyl endopeptidase-like	0.653
F10	SLC3A1	ENSP00000364709	ENSP00000260649	coagulation factor X; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting	solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule	0.657
LAP3	APEH	ENSP00000226299	ENSP00000296456	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser	0.498
LAP3	PREPL	ENSP00000226299	ENSP00000260648	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	prolyl endopeptidase-like	0.676
LAP3	UBC	ENSP00000226299	ENSP00000344818	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	ubiquitin C	0.820
LAP3	USP22	ENSP00000226299	ENSP00000261497	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	ubiquitin specific peptidase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression	0.607
PACRG	CAMKMT	ENSP00000337946	ENSP00000367755	PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease	calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of ’Lys-116’ in calmodulin	0.549
PACRG	PREPL	ENSP00000337946	ENSP00000260648	PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease	prolyl endopeptidase-like	0.623
PACRG	UBC	ENSP00000337946	ENSP00000344818	PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease	ubiquitin C	0.688

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