CALHM2 protein (Homo sapiens) - STRING network view

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CALHM2

calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity) (323 aa)

Predicted Functional Partners:

CNNM2

0.644

NT5C2

0.516

WBP1L

0.502

PIP5KL1

0.501

C10orf32

0.472

HECTD3

0.452

ENSG00000228144

0.420

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf32	CALHM2	ENSP00000299353	ENSP00000260743	chromosome 10 open reading frame 32	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	0.472
C10orf32	WBP1L	ENSP00000299353	ENSP00000414721	chromosome 10 open reading frame 32	WW domain binding protein 1-like	0.407
CALHM2	C10orf32	ENSP00000260743	ENSP00000299353	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	chromosome 10 open reading frame 32	0.472
CALHM2	CNNM2	ENSP00000260743	ENSP00000358894	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)	0.644
CALHM2	ENSG00000228144	ENSP00000260743	ENSP00000454670	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	Protein lifeguard 4; Uncharacterized protein	0.420
CALHM2	HECTD3	ENSP00000260743	ENSP00000361245	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity)	0.452
CALHM2	NT5C2	ENSP00000260743	ENSP00000339479	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	5’-nucleotidase, cytosolic II; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides	0.516
CALHM2	PIP5KL1	ENSP00000260743	ENSP00000373399	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	phosphatidylinositol-4-phosphate 5-kinase-like 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3 (By similarity)	0.501
CALHM2	WBP1L	ENSP00000260743	ENSP00000414721	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	WW domain binding protein 1-like	0.502
CNNM2	CALHM2	ENSP00000358894	ENSP00000260743	cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	0.644
CNNM2	NT5C2	ENSP00000358894	ENSP00000339479	cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)	5’-nucleotidase, cytosolic II; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides	0.515
ENSG00000228144	CALHM2	ENSP00000454670	ENSP00000260743	Protein lifeguard 4; Uncharacterized protein	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	0.420
HECTD3	CALHM2	ENSP00000361245	ENSP00000260743	HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity)	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	0.452
NT5C2	CALHM2	ENSP00000339479	ENSP00000260743	5’-nucleotidase, cytosolic II; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	0.516
NT5C2	CNNM2	ENSP00000339479	ENSP00000358894	5’-nucleotidase, cytosolic II; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides	cyclin M2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)	0.515
PIP5KL1	CALHM2	ENSP00000373399	ENSP00000260743	phosphatidylinositol-4-phosphate 5-kinase-like 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3 (By similarity)	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	0.501
WBP1L	C10orf32	ENSP00000414721	ENSP00000299353	WW domain binding protein 1-like	chromosome 10 open reading frame 32	0.407
WBP1L	CALHM2	ENSP00000414721	ENSP00000260743	WW domain binding protein 1-like	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	0.502

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