TMEM5 protein (Homo sapiens) - STRING network view

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TMEM5

transmembrane protein 5 (443 aa)

Predicted Functional Partners:

GRXCR1

0.692

ATP9B

0.591

BOD1

0.588

MFF

0.553

KATNAL1

0.510

ISPD

0.508

IFITM5

0.506

ATP8A1

0.488

FAM208B

0.472

AP3S1

0.437

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP3S1	ATP9B	ENSP00000325369	ENSP00000398076	adaptor-related protein complex 3, sigma 1 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals	ATPase, class II, type 9B	0.421
AP3S1	TMEM5	ENSP00000325369	ENSP00000261234	adaptor-related protein complex 3, sigma 1 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals	transmembrane protein 5	0.437
ATP8A1	GRXCR1	ENSP00000371084	ENSP00000382670	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles	glutaredoxin, cysteine rich 1; May play a role in actin filament architecture in developing stereocilia of sensory cells (By similarity)	0.890
ATP8A1	TMEM5	ENSP00000371084	ENSP00000261234	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles	transmembrane protein 5	0.488
ATP9B	AP3S1	ENSP00000398076	ENSP00000325369	ATPase, class II, type 9B	adaptor-related protein complex 3, sigma 1 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals	0.421
ATP9B	BOD1	ENSP00000398076	ENSP00000309644	ATPase, class II, type 9B	biorientation of chromosomes in cell division 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles	0.609
ATP9B	MFF	ENSP00000398076	ENSP00000302037	ATPase, class II, type 9B	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	0.565
ATP9B	TMEM5	ENSP00000398076	ENSP00000261234	ATPase, class II, type 9B	transmembrane protein 5	0.591
BOD1	ATP9B	ENSP00000309644	ENSP00000398076	biorientation of chromosomes in cell division 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles	ATPase, class II, type 9B	0.609
BOD1	MFF	ENSP00000309644	ENSP00000302037	biorientation of chromosomes in cell division 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	0.580
BOD1	TMEM5	ENSP00000309644	ENSP00000261234	biorientation of chromosomes in cell division 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles	transmembrane protein 5	0.588
FAM208B	TMEM5	ENSP00000328426	ENSP00000261234	family with sequence similarity 208, member B	transmembrane protein 5	0.472
GRXCR1	ATP8A1	ENSP00000382670	ENSP00000371084	glutaredoxin, cysteine rich 1; May play a role in actin filament architecture in developing stereocilia of sensory cells (By similarity)	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles	0.890
GRXCR1	KATNAL1	ENSP00000382670	ENSP00000369989	glutaredoxin, cysteine rich 1; May play a role in actin filament architecture in developing stereocilia of sensory cells (By similarity)	katanin p60 subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity)	0.568
GRXCR1	TMEM5	ENSP00000382670	ENSP00000261234	glutaredoxin, cysteine rich 1; May play a role in actin filament architecture in developing stereocilia of sensory cells (By similarity)	transmembrane protein 5	0.692
IFITM5	TMEM5	ENSP00000372059	ENSP00000261234	interferon induced transmembrane protein 5; Plays a role in bone mineralization (By similarity)	transmembrane protein 5	0.506
ISPD	TMEM5	ENSP00000385478	ENSP00000261234	isoprenoid synthase domain containing; Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation	transmembrane protein 5	0.508
KATNAL1	GRXCR1	ENSP00000369989	ENSP00000382670	katanin p60 subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity)	glutaredoxin, cysteine rich 1; May play a role in actin filament architecture in developing stereocilia of sensory cells (By similarity)	0.568
KATNAL1	TMEM5	ENSP00000369989	ENSP00000261234	katanin p60 subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity)	transmembrane protein 5	0.510
MFF	ATP9B	ENSP00000302037	ENSP00000398076	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	ATPase, class II, type 9B	0.565

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