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TYW1 TYW1 TYW3 TYW3 ELP3 ELP3 TRMT112 TRMT112 TRMT12 TRMT12 UBC UBC TRMT5 TRMT5 TRMT1 TRMT1 TRMT10A TRMT10A NSUN2 NSUN2 TRMT2A TRMT2A
"TRMT5" - tRNA methyltransferase 5 homolog (S. cerevisiae) in Homo sapiens
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Predicted Interactions
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[Homology]
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TRMT5tRNA methyltransferase 5 homolog (S. cerevisiae); Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding (509 aa)    
Predicted Functional Partners:
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae); Probable S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity) (448 aa)
      score_image     score_image   0.952
TRMT1
tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (659 aa)
      score_image     score_image   0.924
TRMT2A
tRNA methyltransferase 2 homolog A (S. cerevisiae); May be involved in nucleic acid metabolism and/or modifications (625 aa)
      score_image     score_image   0.898
TYW1
tRNA-yW synthesizing protein 1 homolog (S. cerevisiae); Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity) (732 aa)
    score_image score_image     score_image   0.837
TRMT10A
tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity) (339 aa)
      score_image     score_image   0.777
TYW3
tRNA-yW synthesizing protein 3 homolog (S. cerevisiae); Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity) (259 aa)
            score_image   0.771
NSUN2
NOP2/Sun RNA methyltransferase family, member 2; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (767 aa)
      score_image     score_image   0.770
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (125 aa)
      score_image score_image   score_image   0.748
ELP3
elongator acetyltransferase complex subunit 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration (547 aa)
      score_image     score_image   0.696
UBC
ubiquitin C (685 aa)
        score_image       0.675
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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