C12orf4 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

C12orf4

chromosome 12 open reading frame 4 (552 aa)

Predicted Functional Partners:

UBC

0.721

TUBA8

0.537

LOH12CR1

0.521

DDX11

0.518

CPNE8

0.450

AIFM3

0.440

SLC45A3

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM3	C12orf4	ENSP00000382120	ENSP00000261250	apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	chromosome 12 open reading frame 4	0.440
C12orf4	AIFM3	ENSP00000261250	ENSP00000382120	chromosome 12 open reading frame 4	apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	0.440
C12orf4	CPNE8	ENSP00000261250	ENSP00000329748	chromosome 12 open reading frame 4	copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	0.450
C12orf4	DDX11	ENSP00000261250	ENSP00000384703	chromosome 12 open reading frame 4	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5’ to 3’ direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5’-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC [...]	0.518
C12orf4	LOH12CR1	ENSP00000261250	ENSP00000321546	chromosome 12 open reading frame 4	loss of heterozygosity, 12, chromosomal region 1	0.521
C12orf4	SLC45A3	ENSP00000261250	ENSP00000356113	chromosome 12 open reading frame 4	solute carrier family 45, member 3	0.416
C12orf4	TUBA8	ENSP00000261250	ENSP00000333326	chromosome 12 open reading frame 4	tubulin, alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.537
C12orf4	UBC	ENSP00000261250	ENSP00000344818	chromosome 12 open reading frame 4	ubiquitin C	0.721
CPNE8	C12orf4	ENSP00000329748	ENSP00000261250	copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	chromosome 12 open reading frame 4	0.450
CPNE8	DDX11	ENSP00000329748	ENSP00000384703	copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5’ to 3’ direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5’-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC [...]	0.421
CPNE8	TUBA8	ENSP00000329748	ENSP00000333326	copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	tubulin, alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.477
CPNE8	UBC	ENSP00000329748	ENSP00000344818	copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	ubiquitin C	0.854
DDX11	C12orf4	ENSP00000384703	ENSP00000261250	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5’ to 3’ direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5’-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC [...]	chromosome 12 open reading frame 4	0.518
DDX11	CPNE8	ENSP00000384703	ENSP00000329748	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5’ to 3’ direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5’-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC [...]	copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	0.421
DDX11	TUBA8	ENSP00000384703	ENSP00000333326	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5’ to 3’ direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5’-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC [...]	tubulin, alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.567
DDX11	UBC	ENSP00000384703	ENSP00000344818	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5’ to 3’ direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5’-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC [...]	ubiquitin C	0.906
LOH12CR1	C12orf4	ENSP00000321546	ENSP00000261250	loss of heterozygosity, 12, chromosomal region 1	chromosome 12 open reading frame 4	0.521
SLC45A3	C12orf4	ENSP00000356113	ENSP00000261250	solute carrier family 45, member 3	chromosome 12 open reading frame 4	0.416
TUBA8	C12orf4	ENSP00000333326	ENSP00000261250	tubulin, alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	chromosome 12 open reading frame 4	0.537
TUBA8	CPNE8	ENSP00000333326	ENSP00000329748	tubulin, alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	0.477

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