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ZNF396 ZNF396 KBTBD7 KBTBD7 PSMA2 PSMA2 ZNF434 ZNF434 OR8B2 OR8B2 ZNF24 ZNF24 ZNF174 ZNF174 VEGFA VEGFA YY1 YY1 USP11 USP11 MAPRE2 MAPRE2
"ZNF24" - zinc finger protein 24 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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ZNF24zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro (368 aa)    
Predicted Functional Partners:
ZNF434
zinc finger protein 434; May be involved in transcriptional regulation (485 aa)
        score_image     score_image 0.839
VEGFA
vascular endothelial growth factor A (412 aa)
            score_image   0.824
ZNF396
zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors (333 aa)
        score_image   score_image score_image 0.797
MAPRE2
microtubule-associated protein, RP/EB family, member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity) (327 aa)
            score_image   0.750
USP11
ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks (963 aa)
        score_image       0.740
KBTBD7
kelch repeat and BTB (POZ) domain containing 7 (684 aa)
        score_image       0.698
YY1
YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...] (414 aa)
        score_image   score_image score_image 0.662
ZNF174
zinc finger protein 174; Transcriptional repressor (407 aa)
        score_image   score_image score_image 0.647
OR8B2
olfactory receptor, family 8, subfamily B, member 2; Odorant receptor (Potential) (313 aa)
        score_image       0.644
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation (234 aa)
        score_image       0.644
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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