node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD4 | GDE1 | ENSP00000414558 | ENSP00000261386 | abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...] | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | 0.756 |
DSCR3 | EXOC2 | ENSP00000311399 | ENSP00000230449 | Down syndrome critical region gene 3 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.615 |
DSCR3 | GDE1 | ENSP00000311399 | ENSP00000261386 | Down syndrome critical region gene 3 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | 0.632 |
DSCR3 | MAT2B | ENSP00000311399 | ENSP00000325425 | Down syndrome critical region gene 3 | methionine adenosyltransferase II, beta | 0.609 |
DSCR3 | OAZ1 | ENSP00000311399 | ENSP00000464146 | Down syndrome critical region gene 3 | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 | 0.577 |
DSCR3 | PPTC7 | ENSP00000311399 | ENSP00000346255 | Down syndrome critical region gene 3 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.651 |
DSCR3 | UBE2J2 | ENSP00000311399 | ENSP00000383719 | Down syndrome critical region gene 3 | ubiquitin-conjugating enzyme E2, J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity) | 0.613 |
EXOC2 | DSCR3 | ENSP00000230449 | ENSP00000311399 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | Down syndrome critical region gene 3 | 0.615 |
EXOC2 | GDE1 | ENSP00000230449 | ENSP00000261386 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | 0.614 |
EXOC2 | MAT2B | ENSP00000230449 | ENSP00000325425 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | methionine adenosyltransferase II, beta | 0.603 |
EXOC2 | OAZ1 | ENSP00000230449 | ENSP00000464146 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 | 0.588 |
EXOC2 | PPTC7 | ENSP00000230449 | ENSP00000346255 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.617 |
EXOC2 | UBE2J2 | ENSP00000230449 | ENSP00000383719 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | ubiquitin-conjugating enzyme E2, J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity) | 0.604 |
GDE1 | ABHD4 | ENSP00000261386 | ENSP00000414558 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...] | 0.756 |
GDE1 | DSCR3 | ENSP00000261386 | ENSP00000311399 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | Down syndrome critical region gene 3 | 0.632 |
GDE1 | EXOC2 | ENSP00000261386 | ENSP00000230449 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.614 |
GDE1 | MAT2B | ENSP00000261386 | ENSP00000325425 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | methionine adenosyltransferase II, beta | 0.640 |
GDE1 | OAZ1 | ENSP00000261386 | ENSP00000464146 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 | 0.597 |
GDE1 | PPTC7 | ENSP00000261386 | ENSP00000346255 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.635 |
GDE1 | PRAF2 | ENSP00000261386 | ENSP00000365570 | glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | PRA1 domain family, member 2; May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis | 0.646 |