node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS13 | ALB | ENSP00000360997 | ENSP00000295897 | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms | albumin | 0.412 |
ADAMTS13 | F5 | ENSP00000360997 | ENSP00000356771 | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | 0.535 |
ADAMTS13 | GP1BA | ENSP00000360997 | ENSP00000329380 | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms | glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium | 0.484 |
ADAMTS13 | VWF | ENSP00000360997 | ENSP00000261405 | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms | von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma | 0.996 |
ALB | ADAMTS13 | ENSP00000295897 | ENSP00000360997 | albumin | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms | 0.412 |
ALB | F5 | ENSP00000295897 | ENSP00000356771 | albumin | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | 0.961 |
ALB | F9 | ENSP00000295897 | ENSP00000218099 | albumin | coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa | 0.645 |
ALB | GP1BA | ENSP00000295897 | ENSP00000329380 | albumin | glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium | 0.480 |
ALB | GP9 | ENSP00000295897 | ENSP00000303942 | albumin | glycoprotein IX (platelet); The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib | 0.470 |
ALB | ITGA2B | ENSP00000295897 | ENSP00000262407 | albumin | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface | 0.636 |
ALB | ITGB3 | ENSP00000295897 | ENSP00000262017 | albumin | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] | 0.567 |
ALB | SERPINE1 | ENSP00000295897 | ENSP00000223095 | albumin | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.993 |
ALB | VEGFA | ENSP00000295897 | ENSP00000361125 | albumin | vascular endothelial growth factor A | 0.964 |
ALB | VWF | ENSP00000295897 | ENSP00000261405 | albumin | von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma | 0.980 |
F5 | ADAMTS13 | ENSP00000356771 | ENSP00000360997 | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms | 0.535 |
F5 | ALB | ENSP00000356771 | ENSP00000295897 | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | albumin | 0.961 |
F5 | F9 | ENSP00000356771 | ENSP00000218099 | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa | 0.824 |
F5 | ITGA2B | ENSP00000356771 | ENSP00000262407 | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface | 0.479 |
F5 | ITGB3 | ENSP00000356771 | ENSP00000262017 | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] | 0.565 |
F5 | SERPINE1 | ENSP00000356771 | ENSP00000223095 | coagulation factor V (proaccelerin, labile factor); Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.971 |