Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | RSBN1 | round spermatid basic protein 1 (802 aa) | ||||||||||||
Predicted Functional Partners:
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 | SMC4 | structural maintenance of chromosomes 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (1288 aa) |
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0.688 | ||||||||||
 | DEPDC1B | DEP domain containing 1B (529 aa) |
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0.645 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.637 | |||||||||
 | TBC1D16 | TBC1 domain family, member 16; May act as a GTPase-activating protein for Rab family protein(s) (767 aa) |
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0.617 | ||||||||||
 | PRICKLE2 | prickle homolog 2 (Drosophila) (844 aa) |
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0.611 | ||||||||||
 | USP42 | ubiquitin specific peptidase 42; Deubiquitinating enzyme which may play an important role during spermatogenesis (By similarity) (1316 aa) |
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0.604 | ||||||||||
 | C7orf26 | chromosome 7 open reading frame 26 (449 aa) |
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0.590 | ||||||||||
 | DMRTB1 | DMRT-like family B with proline-rich C-terminal, 1 (342 aa) |
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0.582 | ||||||||||
 | SPATA12 | spermatogenesis associated 12 (190 aa) |
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0.581 | ||||||||||
 | PRKACA | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] (351 aa) |
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0.576 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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